RT Journal Article
SR Electronic
T1 Effect of air pollution and greenness on the nasal microbiota in infancy
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA1727
DO 10.1183/13993003.congress-2021.PA1727
VO 58
IS suppl 65
A1 Amanda Gisler
A1 Insa Korton
A1 Markus Hilty
A1 Kees De Hoogh
A1 Danielle Vienneau
A1 Urs Frey
A1 Fabienne Decrue
A1 Olga Gorlanova
A1 Andras Soti
A1 Philipp Latzin
A1 Jakob Usemann
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA1727.abstract
AB Air pollution and greenness are associated with respiratory health in children but underlying mechanisms are not fully understood. We aimed to examine associations between fine particulate matter (PM2.5), nitrogen dioxide (NO2) and greenness (Normalized Difference Vegetation Index (NDVI)) with the early nasal microbiota, known to be relevant for respiratory health.Microbiota characterization was performed using 16S rRNA pyrosequencing of 846 nasal swabs collected biweekly from 47 healthy infants. We investigated the association of PM2.5, NO2 and NDVI with the nasal microbiota. Exposures were individually estimated with spatial-temporal models incorporating satellite data. Generalized additive mixed models were used for analysis.Increased PM2.5 and NO2 were associated with reduced within-subject Ružička dissimilarity (PM2.5: per 1 µg/m3 -0.004, 95%CI -0.008, -0.001; NO2: per 1 µg/m3 -0.004, 95%CI -0.007, -0.001). Whole microbial community comparison revealed distinct profiles in the groups exposed to high (p = 0.032) and medium (p = 0.001) PM2.5 levels. Increased PM2.5 was associated with reduced abundance of Corynebacteriaceae (∆% per 1 µg/m3 -4.9, 95%CI -8.4, -1.3) and Staphylococcaceae (∆% per 1 µg/m3: -4.3, 95%CI: -7.8, -6.7). Increased NO2 was associated with reduced abundance of Corynebacteriaceae (∆% per 1 µg/m3 -6.8, 95%CI -9.8, -3.6). Increased NDVI was associated with reduced abundance of S. aureus (∆% per 0.1 NDVI -24.0, 95%CI -39.7, -4.3).We found associations between air pollution and greenness with the nasal microbiota in healthy infants. This suggests that shaping of the early microbiota and its consecutive role in respiratory health may partly be driven through air pollution and greenness.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA1727.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).