PT  - JOURNAL ARTICLE
AU  - Amanda Gisler
AU  - Insa Korton
AU  - Markus Hilty
AU  - Kees De Hoogh
AU  - Danielle Vienneau
AU  - Urs Frey
AU  - Fabienne Decrue
AU  - Olga Gorlanova
AU  - Andras Soti
AU  - Philipp Latzin
AU  - Jakob Usemann
TI  - Effect of air pollution and greenness on the nasal microbiota in infancy
AID  - 10.1183/13993003.congress-2021.PA1727
DP  - 2021 Sep 05
TA  - European Respiratory Journal
PG  - PA1727
VI  - 58
IP  - suppl 65
4099  - http://erj.ersjournals.com/content/58/suppl_65/PA1727.short
4100  - http://erj.ersjournals.com/content/58/suppl_65/PA1727.full
SO  - Eur Respir J2021 Sep 05; 58
AB  - Air pollution and greenness are associated with respiratory health in children but underlying mechanisms are not fully understood. We aimed to examine associations between fine particulate matter (PM2.5), nitrogen dioxide (NO2) and greenness (Normalized Difference Vegetation Index (NDVI)) with the early nasal microbiota, known to be relevant for respiratory health.Microbiota characterization was performed using 16S rRNA pyrosequencing of 846 nasal swabs collected biweekly from 47 healthy infants. We investigated the association of PM2.5, NO2 and NDVI with the nasal microbiota. Exposures were individually estimated with spatial-temporal models incorporating satellite data. Generalized additive mixed models were used for analysis.Increased PM2.5 and NO2 were associated with reduced within-subject Ružička dissimilarity (PM2.5: per 1 µg/m3 -0.004, 95%CI -0.008, -0.001; NO2: per 1 µg/m3 -0.004, 95%CI -0.007, -0.001). Whole microbial community comparison revealed distinct profiles in the groups exposed to high (p = 0.032) and medium (p = 0.001) PM2.5 levels. Increased PM2.5 was associated with reduced abundance of Corynebacteriaceae (∆% per 1 µg/m3 -4.9, 95%CI -8.4, -1.3) and Staphylococcaceae (∆% per 1 µg/m3: -4.3, 95%CI: -7.8, -6.7). Increased NO2 was associated with reduced abundance of Corynebacteriaceae (∆% per 1 µg/m3 -6.8, 95%CI -9.8, -3.6). Increased NDVI was associated with reduced abundance of S. aureus (∆% per 0.1 NDVI -24.0, 95%CI -39.7, -4.3).We found associations between air pollution and greenness with the nasal microbiota in healthy infants. This suggests that shaping of the early microbiota and its consecutive role in respiratory health may partly be driven through air pollution and greenness.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA1727.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).