PT - JOURNAL ARTICLE AU - Larissa Gorbach TI - Multidrug-resistant tuberculosis in children of Belarus AID - 10.1183/13993003.congress-2021.PA3330 DP - 2021 Sep 05 TA - European Respiratory Journal PG - PA3330 VI - 58 IP - suppl 65 4099 - http://erj.ersjournals.com/content/58/suppl_65/PA3330.short 4100 - http://erj.ersjournals.com/content/58/suppl_65/PA3330.full SO - Eur Respir J2021 Sep 05; 58 AB - Introduction: The number of cases of multidrug-resistant tuberculosis (MDR-TB) is increasing every year in the world. Belarus was one of the 10 countries with the highest burden of MDR-TB in 2016-2020.The aim of the study was to research of cases of MDR-TB compared to cases of drug-sensitive tuberculosis in children.The analyzed group included 26 children with MDR-TB (the first group) and 26 children with drug-sensitive tuberculosis (the second group).Methods: Anamnestic, clinical, bacteriological, X-ray methods and statistical analysis have been applied.Results: Both groups did not differ by quantity of boys and girls. Each group included 14 boys (53,8 %) and 12 girls (46,2 %). The average age of children in both groups was the same: in the first group – 15,6 ± 3,1 years, in the second group - 15,6 ± 3,0 years. Tuberculosis was detected during screening in 17 (65,4%) children of the first group and in 16 (61,5%) children of the second group (χ2 = 0,083; p = 0,774). 13 (50%) children of the first group and 17 (65.4%) children of the second group had cavities in the lungs (χ2 = 1,261; p = 0,262). In the first group, 19 (73,1%) children had family contacts with patients with tuberculosis, in the second group - 14 (53,8%) children (χ2 = 2,073; p = 0,150). Cases of death of parents and relatives from tuberculosis were noted in 11 (42,3%) families of children of the first group and in 1 (3,8%) family of children of the second group. The difference between the groups is significant: χ2 = 10,833; p = <0,001.Conclusions: The deaths of parents and relatives have often been reported in the families of children with MDR-TB. Children from families with cases of death of parents and relatives from tuberculosis are at risk for MDR-TB.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3330.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).