PT  - JOURNAL ARTICLE
AU  - Letitia Trofor
AU  - Mona Dobrin
AU  - Ioana Buculei
AU  - Oana-Elena Rohozneanu
AU  - Radu Crisan-Dabija
AU  - Antigona Trofor
TI  - Oxidative stress induced by secondhand smoking in patients with mixed anxious-depressive disorder
AID  - 10.1183/13993003.congress-2021.PA2437
DP  - 2021 Sep 05
TA  - European Respiratory Journal
PG  - PA2437
VI  - 58
IP  - suppl 65
4099  - http://erj.ersjournals.com/content/58/suppl_65/PA2437.short
4100  - http://erj.ersjournals.com/content/58/suppl_65/PA2437.full
SO  - Eur Respir J2021 Sep 05; 58
AB  - Introduction: Anxiety and depression describe abnormal genetics and environment as relevant risk factors. Among these, exposure to tobacco smoke is recognized to generate oxidative stress and even passive smoking can change inflammatory markers (cytokines) in at least 3 hours from exposure.Aim: To quantify possible factors of oxidative stress production in passive and active smokers diagnosed with mixed anxious-depressive disorder (MADD).Methods: Descriptive and factorial analysis of the biochemical (malondialdehide -MDA, vitamin C, uric acid-UA, total cholesterol, triglyceride, creatinine) parameters of 10/31 +- active and passive/active smokers with MADD, with correlations between oxidative stress, anxiety, and nicotine dependence.Quantifying the possible factors of oxidative stress production in passive and active smoking.Results: Passive smoking added higher oxidative stress and levels of total cholesterol and triglycerides (Table I).Higher anxiety scores were revealed when both active and passive smoking, due to more intense oxidative stress.Table I. Descriptive statistics of the biochemical parameters in active and passive smokers with MADD Conclusions: Higher values for the MDA oxidative stress marker were found in severe anxiety patients with both active and passive smoking.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA2437.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).