RT Journal Article
SR Electronic
T1 Long-term oral corticosteroid-sparing effects of anti-IL5/anti-IL5 receptor treatment
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3732
DO 10.1183/13993003.congress-2021.PA3732
VO 58
IS suppl 65
A1 Anne Sofie Bjerrum
A1 Skjold Tina
A1 Schmid Johannes Martin
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3732.abstract
AB Introduction: Clinical trials have shown oral corticosteroid (OCS) sparing effects of anti-IL5/anti-IL5-receptor treatments. The generalisability of these trials may be limited, due to the rigid inclusion and exclusion criteria, and the short tapering duration. Real-life evidence may bridge the gap between the clinical trials and the clinical practice. We present real-life data on the OCS sparing effects of anti-IL5/anti-IL5-receptor treatments after 12 and 24 months of treatment.Methods: We included severe, eosinophilic asthma patients treated with mepolizumab, reslizumab or benralizumab for 24 months. Data on OCS-dose, FEV1, ACT/ACQ score and blood eosinophils were collected from the patients records before and after 12 and 24 months of anti-IL5/anti-IL5-receptor treatment.Results: At baseline 75% of patients were on daily OCS. This number was reduced to 50% and 28% after one and two years of treatment, p< 0.001. Within the group on daily OCS the median daily dose was reduced from 10 mg (IQR 5-20) Prednisolone at baseline to 3.75 mg (IQR 0-10) and 0 mg (IQR 0-7.5) Prednisolone after 12 and 24 months, p< 0.001. At baseline 29% of patients scored themselves as being wellcontrolled, increasing to 45% and 52% after one and two years of treatment, respectively.Conclusions: The findings in this study add to the generalisability of the clinical studies, showing significant OCS sparing effects of anti-IL5/anti-IL5-receptor treatment in a real-life clinical setting. These findings add to the understanding of the long-term effects of anti-IL5/anti-IL5-receptor treatment, showing an even further and persistent OCS sparing effect after two years of treatment, without jeopardizing the asthma control.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3732.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).