RT Journal Article
SR Electronic
T1 Utility of Interleukin-5 in phenotyping allergic versus non allergic asthma
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3725
DO 10.1183/13993003.congress-2021.PA3725
VO 58
IS suppl 65
A1 Bajaj, Darshan Kumar
A1 Kumar, Naveen
A1 Tyagi, Richa
A1 Bajpai, Jyoti
A1 Kant, Surya
A1 Kushwaha, R A S
A1 Verma, Ajay Kumar
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3725.abstract
AB Objective: In recent years concept of precision medicine for phenotyping disease has come up which is important to offer the personalised treatment. This study was based on assessing serum IL-5 levels in subgroups of allergic and non-allergic asthma based on total serum Immunoglobulin E(IgE)Methods: The study was conducted from Jan-Apr 2020 at KGMU, India.25 patients with diagnosis of bronchial asthma were enrolled with age >12years and then patients were subjected to total serum IgE levels. Based on history of atopy and Serum IgE levels the patients were further divided in allergic and non-allergic subgroups. Serum IL-5 levels were measured in both groups as an attempt to segregate the endotypes.Results: On the basis of history of atopy and serum IgE levels the patients were divided in allergic and non-allergic subgroups with 15 and 10 patients respectively. The allergic subgroup had a mean IgE level of 2273IU/ml with maximum and minimum values of 4600 and 1713 and non-allergic one had a mean value of 81 IU/ml with maximum and minimum values of 66 and 99.The IL-5 levels were elevated in 5 patients of the allergic subgroup with average value of 57.7 pg/ml(values more than 15.6 were considered positive).However no correlation was found between the IgE and IL-5 levels. IL-5 levels were not elevated in the non-allergic subgroup. No statistical gender or phenotypic association could be established.Conclusion: Understanding of asthma phenotypes and endotypes is important because the diverseness of this disease results into varying response to therapies. IL-5 along with IL-4 and 13 plays a pivotal role in the Th-2 eosinophilic inflammation with most of the existing and emerging biologicals targeted towards Th2 cytokines.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3725.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).