RT Journal Article SR Electronic T1 Oral bacterial composition and low lung function in a general population JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP OA2868 DO 10.1183/13993003.congress-2021.OA2868 VO 58 IS suppl 65 A1 Rajesh Shigdel A1 Ane Johannessen A1 Cecilie Svanes A1 Francisco Gomez Real A1 Randi Jacobsen Bertelsen YR 2021 UL http://erj.ersjournals.com/content/58/suppl_65/OA2868.abstract AB Background: Disruption of symbiotic balance of the oral microbiota has been associated with respiratory diseases. However, little is known about the relationship between oral bacteria and lung function.Aims and objectives: To determine the association between oral bacteria and low lung function in a general population.Methods: Oral (gingival) samples were collected concurrently with spirometry in 474 adults (47% males, median age 28 years) from the RHINESSA study, Bergen center. Bacterial DNA from the 16S rRNA gene were isolated from gingival fluid, sequenced by Illumina®MiSeq and assigned taxonomy by the Human Oral Microbiome Database. Percent predicted forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC) were categorised into four groups, <80%, 80-90%,90-100% and >100%.Differential abundance analysis was performed considering those who had predicted FEV1 and FVC >100 % as a reference group using Analysis of Compositions of Microbiomes with Bias Correction with 5% False Discovery Rate, adjusting for weight, education, and smoking.Results: We found that abundance of genera Clostridiales, Achromobacter, Moraxella, were significantly different among those with < 80% predicted FEV1 compared to those with FEV1 >100%, Similarly, genus Dermabacter, Clostridiales, Catonella, Peptostreptococcaceae, Mitsuokella, and Helicobacter were differentially abundant in the oral cavity among those with FVC % predicted < 80% compared to FVC >100%.Conclusion: Oral bacterial composition was significantly different for those with low FEV1 or FVC% predicted as compared to those without low lung function.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, OA2868.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).