RT Journal Article
SR Electronic
T1 Desaturation-distance ratio during field exercise test in lymphangioleiomyomatosis: a cross-sectional study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3902
DO 10.1183/13993003.congress-2021.PA3902
VO 58
IS suppl 65
A1 Douglas Silva Queiroz
A1 Cibele Cristine Berto Marques Da Silva
A1 Alexandre Franco Amaral
A1 Martina Rodrigues Oliveira
A1 Henrique Takachi Moriya
A1 Carlos R. R. Carvalho
A1 Bruno Guedes Baldi
A1 Celso R. F. Carvalho1
YR 2021
UL http://erj.ersjournals.com/content/58/suppl_65/PA3902.abstract
AB Background: Desaturation-distance ratio (DDR) evaluates the oxygen desaturation during field walking tests, it is considered a reliable and simple tool, and has been used to assess functional capacity in subjects with respiratory diseases. Lymphangioleiomyomatosis (LAM) is a rare (1/million) neoplastic disease associated with exercise impairment; however, DDR has not been tested in LAM patients.Objectives: to assess DDR during maximal and submaximal exercise test and its association with lung function parameters.Methods: This study included a cohort of women with LAM. The 6-minute (6MWT) and the incremental shuttle walking (ISWT) tests were performed, and DDR was assessed in both tests. Lung function was assessed at rest by spirometry and body plethysmography. Pearson’s correlation following multiple regression analysis was used to evaluate the association between DDR during 6MWT and ISWT and lung function parameters. Predictive models were constructed considering the best independent coefficient (R2).Results: Forty patients were included (46±10 y/o). The distance walked was 517±65m and 443±127m for the 6MWT and ISWT, respectively. Obstructive airway pattern, reduced carbon monoxide diffusing capacity, and air trapping were found in 60%, 57%, and 15% of patients. DDR value was greater in the ISWT than in 6MWT (6.6 vs 8.3, respectively). Those variables were the independently predicted DDR during submaximal (DDR6MWT) and maximal exercise (DDRISWT).Conclusion: DDR is a useful tool for functional evaluation during maximal and submaximal exercises in patients with LAM and can be predicted by airway obstruction, reduced carbon monoxide diffusing capacity, and air trapping.FootnotesCite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3902.This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).