@article {Talaei2004407, author = {Mohammad Talaei and David A. Hughes and Osama Mahmoud and Pauline M. Emmett and Raquel Granell and Stefano Guerra and Seif O. Shaheen}, title = {Dietary intake of vitamin A, lung function and incident asthma in childhood}, volume = {58}, number = {4}, elocation-id = {2004407}, year = {2021}, doi = {10.1183/13993003.04407-2020}, publisher = {European Respiratory Society}, abstract = {Background Longitudinal epidemiological data are scarce on the relationship between dietary intake of vitamin A and respiratory outcomes in childhood. We investigated whether a higher intake of preformed vitamin A or pro-vitamin β-carotene in mid-childhood is associated with higher lung function and with asthma risk in adolescence.Methods In the Avon Longitudinal Study of Parents and Children, dietary intakes of preformed vitamin A and β-carotene equivalents were estimated by food frequency questionnaire at 7 years of age. Post-bronchodilator forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and forced expiratory flow at 25{\textendash}75\% of FVC (FEF25{\textendash}75\%) were measured at 15.5 years and transformed to z-scores. Incident asthma was defined by new cases of doctor-diagnosed asthma at age 11 or 14 years.Results In multivariable adjusted models, a higher intake of preformed vitamin A was associated with higher lung function and a lower risk of incident asthma: comparing top versus bottom quartiles of intake, regression coefficients for FEV1 and FEF25{\textendash}75\% were 0.21 (95\% CI 0.05{\textendash}0.38; ptrend=0.008) and 0.18 (95\% CI 0.03{\textendash}0.32; ptrend=0.02), respectively; odds ratios for FEV1/FVC below the lower limit of normal and incident asthma were 0.49 (95\% CI 0.27{\textendash}0.90; ptrend=0.04) and 0.68 (95\% CI 0.47{\textendash}0.99; ptrend=0.07), respectively. In contrast, there was no evidence for association with β-carotene. We also found some evidence for modification of the associations between preformed vitamin A intake and lung function by BCMO1, NCOR2 and SCGB1A1 gene polymorphisms.Conclusion A higher intake of preformed vitamin A, but not β-carotene, in mid-childhood is associated with higher subsequent lung function and lower risk of fixed airflow limitation and incident asthma.A higher intake of preformed vitamin A, but not pro-vitamin β-carotene, in mid-childhood was associated with higher subsequent lung function and lower risk of fixed airflow limitation and incident asthma https://bit.ly/3d7PUca}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/58/4/2004407}, eprint = {https://erj.ersjournals.com/content/58/4/2004407.full.pdf}, journal = {European Respiratory Journal} }