RT Journal Article
SR Electronic
T1 European Respiratory Society guidelines for the management of children and adolescents with bronchiectasis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2002990
DO 10.1183/13993003.02990-2020
VO 58
IS 2
A1 Anne B. Chang
A1 Rebecca Fortescue
A1 Keith Grimwood
A1 Efthymia Alexopoulou
A1 Leanne Bell
A1 Jeanette Boyd
A1 Andrew Bush
A1 James D. Chalmers
A1 Adam T. Hill
A1 Bulent Karadag
A1 Fabio Midulla
A1 Gabrielle B. McCallum
A1 Zena Powell
A1 Deborah Snijders
A1 Woo-Jung Song
A1 Thomy Tonia
A1 Christine Wilson
A1 Angela Zacharasiewicz
A1 Ahmad Kantar
YR 2021
UL http://erj.ersjournals.com/content/58/2/2002990.abstract
AB There is increasing awareness of bronchiectasis in children and adolescents, a chronic pulmonary disorder associated with poor quality of life for the child/adolescent and their parents, recurrent exacerbations, and costs to the family and health systems. Optimal treatment improves clinical outcomes. Several national guidelines exist, but there are no international guidelines.The European Respiratory Society (ERS) Task Force for the management of paediatric bronchiectasis sought to identify evidence-based management (investigation and treatment) strategies. It used the ERS standardised methodology that included a systematic review of the literature and application of the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to define the quality of the evidence and level of recommendations.A multidisciplinary team of specialists in paediatric and adult respiratory medicine, infectious disease, physiotherapy, primary care, nursing, radiology, immunology, methodology, patient advocacy and parents of children/adolescents with bronchiectasis considered the most relevant clinical questions (for both clinicians and patients) related to managing paediatric bronchiectasis. 14 key clinical questions (seven PICO (Patient, Intervention, Comparison, Outcome) and seven narrative) were generated. The outcomes for each PICO were decided by voting by the panel and parent/patient advisory group.This guideline addresses the definition, diagnostic approach and antibiotic treatment of exacerbations, pathogen eradication, long-term antibiotic therapy, asthma-type therapies (inhaled corticosteroids and bronchodilators), mucoactive drugs, airway clearance, investigation of underlying causes of bronchiectasis, disease monitoring, factors to consider before surgical treatment, and the reversibility and prevention of bronchiectasis in children/adolescents. Benchmarking quality of care for children/adolescents with bronchiectasis to improve clinical outcomes and evidence gaps for future research could be based on these recommendations.Optimal management of children with bronchiectasis is important. This ERS evidence-based guideline, developed by a multidisciplinary team along with parents of children with bronchiectasis, aims to help clinicians optimise the management of bronchiectasis. https://bit.ly/3pvZ9Yi