TY - JOUR T1 - Breath volatile organic compounds and inflammatory markers in adult asthma patients: negative results from the ALLIANCE cohort JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02127-2020 VL - 57 IS - 2 SP - 2002127 AU - Olaf Holz AU - Benjamin Waschki AU - Henrik Watz AU - Anne Kirsten AU - Mustafa Abdo AU - Frauke Pedersen AU - Markus Weckmann AU - Oliver Fuchs AU - Anna-Maria Dittrich AU - Gesine Hansen AU - Matthias V. Kopp AU - Erika von Mutius AU - Klaus F. Rabe AU - Jens M. Hohlfeld AU - Thomas Bahmer A2 - , Y1 - 2021/02/01 UR - http://erj.ersjournals.com/content/57/2/2002127.abstract N2 - “Breathomics” in asthma is a rapidly growing area of significant scientific interest, as indicated by a recently published review, two research articles, and their accompanying editorials in high impact pneumology journals [1–5]. The repeatedly observed associations between breath volatile organic compounds (VOCs) and sputum or blood inflammatory cells [2, 3] suggest that breathomics are on the brink of introduction as a valuable clinically tool. However, there are also major concerns about unresolved methodological issues and a general paucity of high-quality data [1, 6]. In this letter we detail our concerns with breathomics based on data from a cohort of adult asthma patients with a broad spectrum of clinical phenotypes.Despite recent publications, we are not close to finding a clinically valuable breath VOC biomarker for asthma or asthma phenotypes https://bit.ly/3heTgtK ER -