PT  - JOURNAL ARTICLE
AU  - Xin Dai
AU  - Dinh S. Bui
AU  - Jennifer L. Perret
AU  - Adrian J. Lowe
AU  - Peter A. Frith
AU  - Gayan Bowatte
AU  - Paul S. Thomas
AU  - Graham G. Giles
AU  - Garun S. Hamilton
AU  - Helen Tsimiklis
AU  - Jennie Hui
AU  - John Burgess
AU  - Aung K. Win
AU  - Michael J. Abramson
AU  - E. Haydn Walters
AU  - Shyamali C. Dharmage
AU  - Caroline J. Lodge
TI  - Exposure to household air pollution over 10 years is related to asthma and lung function decline
AID  - 10.1183/13993003.00602-2020
DP  - 2021 Jan 01
TA  - European Respiratory Journal
PG  - 2000602
VI  - 57
IP  - 1
4099  - http://erj.ersjournals.com/content/57/1/2000602.short
4100  - http://erj.ersjournals.com/content/57/1/2000602.full
SO  - Eur Respir J2021 Jan 01; 57
AB  - Introduction We investigated if long-term household air pollution (HAP) is associated with asthma and lung function decline in middle-aged adults, and whether these associations were modified by glutathione S-transferase (GST) gene variants, ventilation and atopy.Materials and methods Prospective data on HAP (heating, cooking, mould and smoking) and asthma were collected in the Tasmanian Longitudinal Health Study (TAHS) at mean ages 43 and 53 years (n=3314). Subsamples had data on lung function (n=897) and GST gene polymorphisms (n=928). Latent class analysis was used to characterise longitudinal patterns of exposure. Regression models assessed associations and interactions.Results We identified seven longitudinal HAP profiles. Of these, three were associated with persistent asthma, greater lung function decline and % reversibility by age 53 years compared with the “Least exposed” reference profile for those who used reverse-cycle air conditioning, electric cooking and no smoking. The “All gas” (OR 2.64, 95% CI 1.22–5.70), “Wood heating/smoking” (OR 2.71, 95% CI 1.21–6.05) and “Wood heating/gas cooking” (OR 2.60, 95% CI 1.11–6.11) profiles were associated with persistent asthma, as well as greater lung function decline and % reversibility. Participants with the GSTP1 Ile/Ile genotype were at a higher risk of asthma or greater lung function decline when exposed compared with other genotypes. Exhaust fan use and opening windows frequently may reduce the adverse effects of HAP produced by combustion heating and cooking on current asthma, presumably through increasing ventilation.Conclusions Exposures to wood heating, gas cooking and heating, and tobacco smoke over 10 years increased the risks of persistent asthma, lung function decline and % reversibility, with evidence of interaction by GST genes and ventilation.Long-term exposure to household air pollution (gas, wood smoke, tobacco smoke and their combinations) is linked to adverse respiratory health in middle age, particularly for those with GST risk variants and living in poorly ventilated houses https://bit.ly/3ammfKu