TY - JOUR T1 - Risk factors associated with the development of interstitial lung abnormalities JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.03005-2020 SP - 2003005 AU - Ivette Buendía-Roldán AU - Rosario Fernandez AU - Mayra Mejía AU - Fortunato Juarez AU - Gustavo Ramirez-Martinez AU - Eduardo Montes AU - Ana Karem S. Pruneda AU - Karen Martinez-Espinosa AU - Aime Alarcon-Dionet AU - Iliana Herrera AU - Carina Becerril AU - Leslie Chavez-Galan AU - Mario Preciado AU - Annie Pardo AU - Moisés Selman Y1 - 2021/01/01 UR - http://erj.ersjournals.com/content/early/2021/01/08/13993003.03005-2020.abstract N2 - Background Around 8–10% of individuals over 50 years, present interstitial lung abnormalities (ILA), but their risk factors are uncertain.Methods From 817 individuals recruited in our “Lung Aging Program”, 80 (9.7%) showed ILA and were compared with 564 individuals of the same cohort with normal HRCT to evaluate demographic and functional differences, and with 80 individuals, randomly selected from the same cohort for biomarkers. We evaluated MUC5B (rs35705950) variant, telomere length, and serum levels of matrix metalloproteinases (MMP)-1, -2, -3, -7, -8, -9, -12, -13, interleukin (IL)-6, surfactant protein (SP)-D, alpha-Klotho and resistin.Results Individuals with ILA were usually males (p<0.005), older than controls (<0.0001), smokers (p=0.01), with greater frequency of MUC5B rs35705950 (OR 3.5; CI 95% 1.29–9.44, p=0.01), and reduced DLCO and oxygen saturation. Resistin, IL-6, SP-D, MMP-1, MMP-7, and MMP-13 were significantly increased in individuals with ILA. Resistin (12±5 ng mL−1 versus 9±4 ng·mL−1; p=0.0005) and MMP-13 (357±143 versus 298±116, p=0.004 pg·mL−1), were the most increased biomarkers. On follow-up (24±18 months), 18 individuals showed progression which was associated with gastroesophageal reflux disease (OR 4.1 CI 95% 1.2–12.9, p=0.02), and in females with diabetes mellitus (OR 5.3, CI 95% 1.03–27.4, p=0.01).Conclusions Around 10% of asymptomatic respiratory individuals enrolled in our lung aging program show interstitial lung abnormalities. Increased serum concentrations of pro-inflammatory molecules and MMPs are associated with ILA.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Fernandez has nothing to disclose.Conflict of interest: Dr. Juarez has nothing to disclose.Conflict of interest: Dr. Ramirez-Martinez has nothing to disclose.Conflict of interest: Dr. Montes has nothing to disclose.Conflict of interest: Dr. Martinez-Espinosa has nothing to disclose.Conflict of interest: Dr. Alarcon-Dionet has nothing to disclose.Conflict of interest: Dr. Herrera has nothing to disclose.Conflict of interest: Dr. Becerril has nothing to disclose.Conflict of interest: Dr. Chavez-Galan has nothing to disclose.Conflict of interest: Dr. Preciado has nothing to disclose.Conflict of interest: Dr. Pardo has nothing to disclose.Conflict of interest: Dr. Selman has nothing to disclose.Conflict of interest: Dr. Buendia-Roldan has nothing to disclose.Conflict of interest: Dr. Mejia has nothing to disclose.Conflict of interest: Dr. S.Pruneda has nothing to disclose. ER -