TY - JOUR T1 - Pragmatic global dosing recommendations for the 3-month, once-weekly rifapentine and isoniazid preventive TB regimen in children JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01756-2020 VL - 57 IS - 1 SP - 2001756 AU - Kendra K. Radtke AU - Jennifer E. Hibma AU - Anneke C. Hesseling AU - Rada M. Savic Y1 - 2021/01/01 UR - http://erj.ersjournals.com/content/57/1/2001756.abstract N2 - The End TB Strategy, proposed by the World Health Organization (WHO) in 2014, calls for a 90% reduction in tuberculosis (TB)-related deaths and an 80% reduction in TB incidence by 2030 [1]. TB remains a leading cause of death in children under 5 years of age [2], and interventions to eliminate preventable child deaths from TB are urgently needed. Additional and effective TB prevention measures are crucial for the End TB Strategy goals to be met [3].This study proposes a revised synchronised and pragmatic dosing table for the 3HP regimen in children that utilises available formulations. The revised doses are predicted to deliver adequate rifapentine and isoniazid exposure in children. https://bit.ly/3eUHm86 ER -