TY - JOUR T1 - Acid-suppressive medications in the first year of life and risk of childhood asthma: a population-based birth cohort study JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00197-2020 VL - 56 IS - 5 SP - 2000197 AU - Claudio Barbiellini Amidei AU - Rosanna Comoretto AU - Loris Zanier AU - Daniele DonĂ  AU - Anna Cantarutti AU - Cristina Canova Y1 - 2020/11/01 UR - http://erj.ersjournals.com/content/56/5/2000197.abstract N2 - Asthma is the most frequent immune-mediated chronic condition among children, and is associated with genetic risk factors as well as specific prenatal and early-life exposures [1]. Gastro-oesophageal reflux disease (GORD) is a common paediatric condition [2], associated with bronchospasms in infants, and has been considered a possible risk factor for the development of asthma, although the results are inconsistent [2, 3]. The treatment for GORD is based on acid-suppressive medications, mainly proton pump inhibitors (PPIs) and H2 receptor antagonists (H2RAs) [4].Exposure to acid-suppressive medications in the first year of life is associated with a marked increase in the risk of developing childhood asthma; further studies are required to assess the causal relationship that underlies this association https://bit.ly/2BdAzaJ ER -