TY - JOUR T1 - Oxygen enhanced MRI biomarkers of lung function in interstitial lung disease JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.4330 VL - 56 IS - suppl 64 SP - 4330 AU - Marta Tibiletti AU - Josephine Naish AU - Matthew J Heaton AU - John Waterton AU - Paul Hughes AU - James A Eaden AU - Sarah Skeoch AU - Nazia Chaudhuri AU - Ian Bruce AU - Stephen M. Bianchi AU - Jim Wild AU - Geoff Jm Parker Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/4330.abstract N2 - Introduction: Novel biomarkers are needed to improve assessment of ILD. Oxygen enhanced MRI (OE-MRI) monitors regional O2 delivery from changes in the MRI relaxation time T1 in response to hyperoxia. We present OE-MRI biomarkers in different ILD phenotypes (IPF, DI-ILD, CTD-ILD, HSP) acquired in a prospective observational study and compare them with lung function tests under standard clinical care.Methods: Patients recruited and scans analysed to date are summarised in fig 1. The OE MR parameters considered were: baseline T1, change in delta pO2 (ΔpO2), O2 wash-in time and ventilated volume fraction. Biomarker values at each visit and the change between visits were compared with lung function tests (FVC%, FEV1%, Tlco%, KCO%) using Pearson correlation (no correction for multiple comparisons).Results: In the IPF subgroup, T1 correlated with Tlco% and KCO% (r=-0.43, p=0.027 and r=-0.43, p=0.028). Changes between visits in ΔpO2 and in KCO%(r = 0.86, p=0.003) were also correlated. No significant correlations were found in other phenotypes.Conclusions: In IPF, change between visits in ΔpO2 correlates with the change in KCO%, but not in the other ILD subtypes. FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4330.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -