RT Journal Article
SR Electronic
T1 The Extended Salford Lung Study: an EHR-based extension of the SLS trials
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 3286
DO 10.1183/13993003.congress-2020.3286
VO 56
IS suppl 64
A1 Jeanne Pimenta
A1 Wilhelmine Meeraus
A1 Richard Yeatman
A1 Alan Barth
A1 Tanith Hjelmbjerg
A1 Jamila Astrom
A1 Loretta Jacques
A1 Sheila Mccorkindale
A1 Mark Fry
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/3286.abstract
AB The Salford Lung Studies (SLS) were real-world effectiveness RCTs of initiating FF/VI vs. usual care (1:1) in asthma and COPD. Data were only collected in SLS for a relatively short period, limiting study of long-term outcomes. The Extended-SLS aims to augment the SLS, collecting 1° and 2° care electronic health record (EHR) data and patient questionnaires.After receiving Ethics approval, GPs remotely consented SLS subjects (mean 3.2 yrs post-completion). To facilitate GPs in identifying eligible patients, a novel EHR-based approach was used to flag subjects who completed the SLS, were still alive and registered with the same GP. An automated system (Docmail) was used to send consent forms/questionnaires direct to patients. Medical data were collected solely via EHRs; a trusted 3rd party extracted 1°-care data from GPs systems and NHS Digital provided linked 2°-care data.Of the 75 GP sites from the original SLS, 35 did not participate, resulting in 4,158 potentially eligible subjects from 40 practices; 18% were excluded as could not be confirmed as SLS subjects or incapacity. Of 2,989 invited, 39% consented to the study (see Figure).We demonstrate that developing an EHR-based, trial extension is achievable with good consent rates. Leveraging of EHRs and technology reduced GP burden, facilitating participation. Initiation of extension studies prior to study close out may help in reducing patient attrition.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3286.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).