TY - JOUR T1 - EAT, BREATHE, SLEEP with Osteogenesis Imperfecta (OI) JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.2947 VL - 56 IS - suppl 64 SP - 2947 AU - Antonella LoMauro AU - Ramona De Amicis AU - Vittorio Landoni AU - Giulia De Carlo AU - Alice Delle Donne AU - Luana Vicentini AU - Paolo Fraschini AU - Simona Bertoli AU - Andrea Aliverti Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/2947.abstract N2 - Introduction: Although OI is an inherited connective tissue disorder, it is limitative to consider it only as a skeletal disease. Many factors make OI patients prone to sleep and respiratory problems:craniofacial alteration, kyphoscoliosis and ribcage deformity. The former predisposes toward upper airway collapse during sleep, the others toward restriction and altered action of ribcage muscles. OI patients may experience overweight/obesity, secondary to physical inactivity and/or disproportional growth, that furhter exacerbates sleep/respiratory/orthopedics impairments.Aims and Objectives: To implement a multidisciplinary study that considers sleep, breathing and body composition in OI, since no litterature is available.Methods: Nocturnal oxygen saturation, spirometry, awake breathing pattern and body composition (assesed by DEXA) were evaluated on 27 adult OI patients(age:34.5yrs).Results: AHI and ODI index showed that obstructive sleep apnea(OSA) was present in 13 patients who were characterized by: lower vital capacity, rapid and shallow breathing, reduced pulmonary ribcage expansion, higher body fat percentage (particularly in the neck) and higher fat to lean ratio(Figure1).Conclusions: The incidence of OSA in OI was 48%, being associated to poor respiratory function and obesity. These findings suggest that sleep, breathing and nutrition assessment should be routinely evaluated in OI, because they might have an important impact on the quality of life.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2947.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -