RT Journal Article SR Electronic T1 Predictors of Residual Pulmonary Vascular Obstruction after Pulmonary Embolism: results from a prospective cohort study JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1860 DO 10.1183/13993003.congress-2020.1860 VO 56 IS suppl 64 A1 Francis Couturaud A1 Gael Picart A1 Philippe Robin A1 Cécile Tromeur A1 Raphael Le Mao A1 Leela Raj A1 Christophe Leroyer YR 2020 UL http://erj.ersjournals.com/content/56/suppl_64/1860.abstract AB Background: We aimed to determine the prevalence of residual pulmonary vascular obstruction (RPVO) after symptomatic pulmonary embolism (PE) and to identify risk factors for RPVO.Methods: On the basis of a prospective cohort of patients with a documented symptomatic venous thromboembolism, we included patients who had an acute PE and underwent a ventilation/perfusion lung scan at 3 to 24 months during the follow-up after PE. RPVO score was assessed for each patient. Initial pulmonary vascular obstruction at PE diagnosis was also assessed when available. Univariable and multivariable analyses were performed with preselected data to identify predictors for persistent defect defined as RPVO≥5%.Results: Among the 537 included patients, 278 (51.8%) had RPVO≥5%, and 191 (35.6%) had RPVO≥10%. In primary multivariate analysis on overall population, age≥65 years (Odds Ratio (OR: 2.25, 95% CI, 1.45-3.52) and chronic respiratory failure (OR: 3.19, 95% CI, 1.22-10.04) were independent predictors of RPVO≥5%. In secondary multivariate analysis restricted to 256 patients with available initial pulmonary vascular obstruction score at index PE (IPVO), age≥65 years (OR: 2.78, 95% CI, 1.41-5.53), unprovoked PE (OR: 2.11, 95% CI, 1.11-4.07) and IPVO≥20% (OR: 2.94, 95% CI, 1.68-5.20) were found to be independent risk factors for RVPO ≥5%.Conclusion: After an acute PE, age≥65 years, unprovoked PE and IPVO≥20% at PE diagnosis appeared to be risk factors for residual pulmonary vascular obstruction at three to 24 months.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1860.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).