TY - JOUR T1 - Regional hyperpolarised 129-xenon diffusion-weighted MRI in patients with IPF JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.4333 VL - 56 IS - suppl 64 SP - 4333 AU - James Eaden AU - Ho-Fung Chan AU - Nicholas Weatherley AU - Stephen Bianchi AU - Jim Wild Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/4333.abstract N2 - Introduction: Apparent diffusion coefficient (ADC) and mean diffusive length scale (LmD) are diffusion-weighted (DW) MRI measurements of hyperpolarised gas diffusion barrier lengths in the alveolar airspaces, providing novel lung microstructure information.Methods: This is a prospective, observational study of IPF patients from a tertiary centre. 3D DW-MRI was performed on a 1.5T scanner with inhaled hyperpolarised 129-xenon (129Xe). Regional DW-MRI values were produced by separating each coronal lung slice into three zones. PFTs were performed on the same day as the MRI scans.Results: To date, 31 patients have undergone baseline 129Xe DW-MRI and 14 have returned at six-months. At baseline, a significant difference in mean 129Xe ADC was seen between the middle and upper zones (p<0.001), but not between the lower and middle (p=0.17) or the lower and upper zones (p=0.26). Similarly, a significant difference in mean 129Xe LmD was observed between the middle and upper zones (p=0.011), but not between the lower and middle (p>0.99) or the lower and upper zones (p=0.13). There was no significant longitudinal change in mean 129Xe ADC for each of the lung zones. There was a significant longitudinal change in mean 129Xe LmD in the lower (p=0.006) and middle zones (p=0.03), but not the upper zone (p=0.14). The was no significant longitudinal change in FVC% or DLCO% predicted.Discussion: Regional hyperpolarised 129Xe LmD was more sensitive to longitudinal change than 129Xe ADC and PFTs, in keeping with previous helium DW-MRI findings (Chan H-F et al. Radiology 2019; 291:223-229). 129Xe DW-MRI may be a useful imaging biomarker to assess disease progression and can provide further insight into the lung microstructure in IPF.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4333.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -