RT Journal Article SR Electronic T1 Investigation of bioresorbable porous implants based on polylactide and polycaprolactone JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 3136 DO 10.1183/13993003.congress-2020.3136 VO 56 IS suppl 64 A1 K.V. Tokaev A1 I.A. Vasilieva A1 Ju.R. Zyuzya A1 T.E. Grigoriev A1 T.K. Tokaev A1 V.K. Tokaev A1 A.S. Bikbaev A1 K.I. Lukanina A1 Ju.D. Zagoskin A1 V.I. Sevastianov YR 2020 UL http://erj.ersjournals.com/content/56/suppl_64/3136.abstract AB Introduction: One of the urgent problems of thoracic surgery is the development of a bioresorbable porous matrix for intra, or extrapleural implantation in patients with drug-resistant pulmonary tuberculosis. Another important task is the in situ formation of a “biological filling” as an alternative method for correcting the volume of a pleural cavity during the lung surgery.Aims: We studied the local tissue effect of laboratory samples of highly porous matrices with different polylactide/polycaprolactone (PLA/PCL) ratios in rats.Methods and Matherials: The method of subcutaneous implantation in vivo was used. The following samples were in the experiment: № 1 – 3.0%; № 2 – 4.0%; № 3 – 1.7%, while the ratio of polymers in solution was respectively: 3/1; 1/3 and 1/1 PLA/PCL. The method of obtaining highly porous implants was lyophilization. The porosity of the samples ranged from 96.0 to 98.3%. Physical and mechanical tests showed that Young's modulus varies from 100 to 1800 kPa. In the control group, a sheath of a silicone implant from Mentor was used. The terms of rat’s explantation were 1-2-3-4-5-8-12-14 weeks.Results: When histological examination the more favorable reaction develops using samples № 1, 2 and 3. At the same time, there are signs of resorption of the implant material, its replacement with a fibrous tissue, vascularization and encapsulation, without a perifocal inflammatory process and reactive nature changes. No differences were found between implant modifications.Conclusions: Thus, the in vivo experimental studies show the high biocompatibility of porous matrices based on PLA/PCL as potential materials for the pleural implants development.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3136.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).