RT Journal Article
SR Electronic
T1 Early-life exposure to air pollution and lung function development into adolescence: the GINIplus/LISA birth cohorts
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4982
DO 10.1183/13993003.congress-2020.4982
VO 56
IS suppl 64
A1 Qi Zhao
A1 Iana Markevych
A1 Dietrich Berdel
A1 Andrea Berg
A1 Monika Gappa
A1 Sibylle Koletzko
A1 Carl-Peter Bauer
A1 Holger Schulz
A1 Marie Standl
A1 Joachim Heinrich
A1 Tamara Schikowski
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/4982.abstract
AB Background: Limited evidence exists on how exposure to air pollution during infancy may affect lung function development into adolescence.Objectives: To investigate the association between early-life air pollution exposure and change in lung function until age 15.Methods: In the GINIplus and LISA birth cohorts, 915 children from two German regions, Munich and Wesel, were investigated, who had at least two spirometric measurements at the age six, 10 and 15. Z-scores of FEV1 and FVC were calculated according to reference values for children in Germany. Annual average concentrations of nitrogen dioxide, particulate matter with diameters <2.5, <10 and 2.5–10µm (PM2.5, PM10 and PMcoarse), and PM2.5 absorbance at birth addresses were estimated by land-use regression models. Associations between early exposure and lung function changes were fitted using linear mixed models.Results: In Wesel, for per interquartile range increase in air pollutants during the first year of life, z-scores declined annually by -0.009 (95%CI: -0.011; -0.007) to -0.021 (95%CI: -0.026; -0.015) for FEV1, and by -0.004 (95%CI: -0.006; -0.002) to -0.010 (95%CI: -0.016; -0.004) for FVC. In Munich, the attenuations were only statistically significant for FEV1 [range: -0.017 (95%CI: -0.027; -0.007) to -0.027 (95%CI: -0.047; -0.008)]. Reduced lung function was higher for children who developed asthma between 3-15 years (although insignificant) and for those with breastfeeding less than 12 weeks.Conclusions: Early-life exposure to higher air pollution was associated with reduced lung function until adolescence. Breastfeeding may potentially reduce the risk of early air pollution on impaired lung function.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4982.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).