PT  - JOURNAL ARTICLE
AU  - Stuart Innes
AU  - Erik Skyllberg
AU  - Helen Fielden
AU  - Ateeb Khan
AU  - Daryl Cheng
AU  - Rizwan Kaiser
AU  - Adam Ainley
TI  - Late Breaking Abstract - Thromboembolic complications in COVID-19 patients admitted to two large East London hospitals
AID  - 10.1183/13993003.congress-2020.4039
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 4039
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/4039.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/4039.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Introduction: COVID-19 may predispose to both venous and arterial thromboembolism, with reports of increased incidence of thromboembolic complications noted in the literature (Lodigiani et al, Thrombosis research, 2020, 191:9-14). We aimed to determine the incidence of thromboembolic complications in patients presenting with COVID-19.Method: We performed a retrospective cohort study of 234 consecutive adult admissions with a confirmed or suspected diagnosis of COVID-19, admitted to the respiratory wards of two hospitals in East London, UK between 10 March and 26 April 2020.Results: We included 234 patients (median age 66 years, 66% male). CT pulmonary angiogram (n=26), CT head (n=26) and leg Doppler ultrasound (n=13) were the most common radiological investigations performed to investigate for possible thromboembolic events. A total of 14 thromboembolic complications occurred in 12/234 patients (5.1%). There were seven pulmonary emboli (3.0% of all patients, 26% of all CTPAs performed), four ischaemic strokes (1.7%) and three lower limb deep vein thromboses (1.3%). Where measured, the D-dimer was significantly raised in patients with confirmed thrombosis. The average peak D-dimer during admission was 15.5mg/L in patients with confirmed thrombosis compared to 8.8mg/L in patients with no thrombosis.Conclusion: COVID-19 is associated with increased risk of venous and arterial thromboembolic events. Individual D-dimer levels are difficult to interpret. Our data suggests that higher mean D-dimers are indicative of a thrombotic event and could identify high risk groups of VTE in patients with COVID-19.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4039.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).