PT  - JOURNAL ARTICLE
AU  - Huseyin Hakan Mursaloglu
AU  - Can Akin
AU  - Cansu Yilmaz
AU  - Pinar Ergenekon
AU  - Yasemin Gokdemir
AU  - Ela Erdem Eralp
AU  - Fazilet Karakoc
AU  - Aysegul Karahasan
AU  - Bulent Karadag
TI  - Predictors of eradication failure at first isolation of MRSA in cystic fibrosis patients
AID  - 10.1183/13993003.congress-2020.692
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 692
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/692.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/692.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Introduction: The prevalence of MRSA in patients with CF has risen in recent years with potentially harmful effects on lung function and disease progress.Aims and Objectives: We aimed to determine predictors of eradication failure.Methods: 309 patients were involved in the study. All sputum cultures collected between 2015-2019 were reviewed. Clinical findings, demographics and eradication regimens were compared retrospectively.Results: The mean age of patients at first MRSA isolation was 9,32 ± 5,79. 22 patients out of 61 positive MRSA cultures (36,1) were eradicated. Pancreatic insufficiency was the only statistically significant predictor of MRSA eradication failure (OR=0,179 p=0,027). Sex, age, age at diagnosis, anthropometric measurements, microbial resistance of pathogen, FEV1, biliary-hepatic disease, dornase alfa or inhaled corticosteroid use, hospitalization and exacerbation rate and ΔF508 mutation were not statistically significant as a predictor.Conclusions: There is limited data investigating morbidity and mortality of chronic MRSA infection. This study has shown that pancreatic insufficiency is one of the predictors of eradication failure. Further prospective studies should be done to determine the best treatment option and impact of MRSA on disease progress.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 692.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).