PT  - JOURNAL ARTICLE
AU  - Hana Müllerová
AU  - Donna K Finch
AU  - Alvar Agustí
AU  - Marianna Alacqua
AU  - Gary P Anderson
AU  - Richard Beasley
AU  - Laura Belton
AU  - Alex De Giorgio-Miller
AU  - J Mark Fitzgerald
AU  - Rod Hughes
AU  - Ian D Pavord
AU  - David Price
AU  - Eleni Rapsomaniki
AU  - Mohsen Sadatsafavi
AU  - Jørgen Vestbo
AU  - Elisabeth H Bel
TI  - Clinical factors associated with baseline blood eosinophils among patients with asthma or COPD: NOVELTY study
AID  - 10.1183/13993003.congress-2020.2990
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 2990
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/2990.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/2990.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Background: Blood eosinophil count (bEOS) is an important biomarker in obstructive lung disease. NOVELTY (NCT02760329) is a global, prospective, observational study with potential to identify obstructive lung disease phenotypes associated with differential outcomes, using biomarkers and clinical features.Objective: To evaluate factors associated with bEOS in patients with either physician-assigned asthma or COPD in NOVELTY.Methods: A cross-sectional analysis of associations between a single bEOS measurement and other baseline characteristics was performed using univariate and multivariate regression models.Results: Of 4,538 patients with data, the geometric mean (SE) bEOS was 0.16 (0.002) x109/L. Of these, 864 (19%) had EOS ≥300 cells/µL (23% asthma; 14% COPD). High bEOS was positively associated with male sex, ≥2 symptom worsenings in prior 3 months, FeNO, FEV1 reversibility, obesity and frequent mucoid cough, in both asthma and COPD (Figure). For asthma, positive associations with higher bEOS were observed for reduced lung function and physician-assessed severity; for COPD, positive associations were observed with current/former smokers. Associations with FeNO and frequent mucoid cough persisted in multivariate models for both diagnoses.Conclusions: Higher bEOS was independently associated with higher FeNO and presence of frequent mucoid cough regardless of physician-assigned asthma or COPD.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2990.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).