PT - JOURNAL ARTICLE AU - Müllerová, Hana AU - Finch, Donna K AU - Agustí, Alvar AU - Alacqua, Marianna AU - Anderson, Gary P AU - Beasley, Richard AU - Belton, Laura AU - De Giorgio-Miller, Alex AU - Fitzgerald, J Mark AU - Hughes, Rod AU - Pavord, Ian D AU - Price, David AU - Rapsomaniki, Eleni AU - Sadatsafavi, Mohsen AU - Vestbo, Jørgen AU - Bel, Elisabeth H TI - Clinical factors associated with baseline blood eosinophils among patients with asthma or COPD: NOVELTY study AID - 10.1183/13993003.congress-2020.2990 DP - 2020 Sep 07 TA - European Respiratory Journal PG - 2990 VI - 56 IP - suppl 64 4099 - https://publications.ersnet.org//content/56/suppl_64/2990.short 4100 - https://publications.ersnet.org//content/56/suppl_64/2990.full SO - Eur Respir J2020 Sep 07; 56 AB - Background: Blood eosinophil count (bEOS) is an important biomarker in obstructive lung disease. NOVELTY (NCT02760329) is a global, prospective, observational study with potential to identify obstructive lung disease phenotypes associated with differential outcomes, using biomarkers and clinical features.Objective: To evaluate factors associated with bEOS in patients with either physician-assigned asthma or COPD in NOVELTY.Methods: A cross-sectional analysis of associations between a single bEOS measurement and other baseline characteristics was performed using univariate and multivariate regression models.Results: Of 4,538 patients with data, the geometric mean (SE) bEOS was 0.16 (0.002) x109/L. Of these, 864 (19%) had EOS ≥300 cells/µL (23% asthma; 14% COPD). High bEOS was positively associated with male sex, ≥2 symptom worsenings in prior 3 months, FeNO, FEV1 reversibility, obesity and frequent mucoid cough, in both asthma and COPD (Figure). For asthma, positive associations with higher bEOS were observed for reduced lung function and physician-assessed severity; for COPD, positive associations were observed with current/former smokers. Associations with FeNO and frequent mucoid cough persisted in multivariate models for both diagnoses.Conclusions: Higher bEOS was independently associated with higher FeNO and presence of frequent mucoid cough regardless of physician-assigned asthma or COPD.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2990.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).