PT  - JOURNAL ARTICLE
AU  - Grace Jacqueline Oscullo Yepez
AU  - Alberto Garcia Ortega
AU  - Eva Mañas Baena
AU  - Raquel Lopez Reyes
AU  - Aldara Garcia Sanchez
AU  - Irene Cano Pumarega
AU  - Juan Jose Jimenez Aguilella
AU  - Pilar Calvillo Batles
AU  - Jose Daniel Gomez Olivas
AU  - Alba Ceveró Rubio
AU  - Enrique Zaldivar Olmeda
AU  - Tomas Posadas Blazquez
AU  - Maria Jose Selma Ferrer
AU  - David Jimenez Castro
AU  - Miguel Angel Martínez García
TI  - Prevalence of obstructive sleep apnea in acute phase of pulmonary embolism: Preliminary results of ESAET study
AID  - 10.1183/13993003.congress-2020.2505
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 2505
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/2505.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/2505.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Introduction: Currently, Sleep-Disordered breathing has recognized prothrombotic effects and there is growing evidence that obstructive sleep apnea (OSA) is highly prevalent in pulmonary embolism (PE) and might increase its risk.Aims: To assess the prevalence of OSA in the acute phase of PE, and the association between OSA and the presence of right ventricular (RV) dysfunctionMethods: We performed a multicenter and observational study in consecutive hemodynamically stable patients with acute symptomatic PE. Recruited patients underwent an overnight sleep study and transthoracic echocardiography within the first 48 hours of diagnosis.Results: 82 patients have been recruited. Mean apnea-hypopnea index (AHI) was 24/h (SD 21.27), 66 patients (80.5%) with OSA criteria (AHI≥5h). Patients with AHI≥15/h presented significantly higher thrombus load by computerized tomography (CT) (49% vs 47%; p=0.013) and by D-dimer levels (50% vs 44%; p=0.094); and impaired RV function measured by RV/left ventricle ratio>0.9 (27% vs 23%; p=0.03). We also observed an elevated PE severity score defined by PESIs score ≥1 in these patients, but it was not statistically significant (83% vs 72%; p=0.25). Multiple logistic regression analysis revealed an association between patients with AHI ≥ 15/h and thrombus load (OR 3.1; CI 95%, 1.2-7.5; p=0.018), and impaired RV functions (OR 1.7; CI95%, 1.1-4.2; p=0.032), when adjusted by PESIs score, gender and body mass index.Conclusion: OSA is highly prevalent in patients with hemodynamically stable acute PE. Patients with acute PE and moderate-severe OSA (AHI≥15/h) had more PE severity, characterized by greater thrombotic burden and presence of RV dysfunction.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2505.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).