TY - JOUR T1 - Somatotypes trajectories during adulthood and its association with COPD phenotypes JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.2064 VL - 56 IS - suppl 64 SP - 2064 AU - Miguel Divo AU - Marta Marin Oto AU - Ciro Casanova AU - Carlos Cabrera Lopez AU - Juan Pablo De-Torres AU - Jose M. Marin AU - Craig Hersh AU - Ana Ezponda AU - Victor Pinto-Plata AU - Francesca Polverino AU - James Ross AU - Dawn Demeo AU - Gorka Bastarrika AU - Edwin Silverman AU - Bartolome Celli Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/2064.abstract N2 - COPD comprises distinct phenotypes characterized by airflow limitation.Methods: Somatotype changes-as surrogate of adiposity- from early adulthood follow different trajectories to reach distinct phenotypes. Using the validated Stunkard’s pictogram, 356 COPD patients chose the somatotype that best reflects their current body build and those at ages 18, 30, 40 and 50. A group-based trajectory modelling was used to determine somatotypes trajectories. We then compared the current phenotypic characteristics for subjects belonging to each trajectory.Results: At age 18, 88% of subjects described having a lean or medium somatotype (estimated BMI between 19-23 kg·m−2) while the other 12% a heavier somatotype. From age 18, 5 distinct trajectories were observed. Four demonstrating a continuous increase in adiposity throughout adulthood with one exception, where the initial increase was followed by loss of adiposity after age 40. Patients with this trajectory were primarily females with low BMI and DLCO. A persistently lean trajectory was seen in 14% of the cohort. This group had lower FEV1, DLCO, more emphysema and worse BODE score thus resembling the Multiple Organ Loss of Tissue (MOLT) phenotype.Conclusion: COPD patients have distinct somatotype trajectories throughout adulthood. Those with the MOLT phenotype maintain a lean trajectory throughout life. Smoking subjects with this lean phenotype in early adulthood deserve particular attentionFootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2064.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -