RT Journal Article
SR Electronic
T1 Oxygen uptake measured at the ventilatory threshold is a mortality marker in COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4401
DO 10.1183/13993003.congress-2020.4401
VO 56
IS suppl 64
A1 Georges, Thomas
A1 Courat, Salome
A1 Le Vaillant, Marc
A1 Ouksel, Hakima
A1 Chambellan, Arnaud
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/4401.abstract
AB Background: Cardiopulmonary Exercise Testing (CPET) in patients suffering from chronic obstructive pulmonary disease (COPD) has already proved his value for the assessment of prognosis in such patients, especially through the peak oxygen uptake (peak V’O2).Aim: To assess if V’O2 measured at ventilatory threshold is efficient to predict mortality in COPD patientsMethods: Data were available from two cohorts in a university hospital centre in France. COPD patients which have performed a CPET at the beginning of a pulmonary rehabilitation program between 2008 and 2018 were included.Results: Among 104 patients included, 29 died during their follow-up. The V’O2 at the ventilatory threshold, expressed in percentage of the predicted peak V’O2, was identified as a prognostic factor (HR 0.954, 95% ci : 0.921 - 0.989). In a multivariable logistic regression model, including sex, age, heart failure and negative chronotropic treatment, this variable remained associated with mortality (HR 0.944, 95% CI 0.908 - 0.982). The peak V'O2 (percentage reference value) was also associated with mortality as expected (HR 0.953, IC95% 0.924 - 0.982).Conclusion: V’O2 measured at the ventilatory threshold could be one of the best criterion to predict mortality. It has the advantage to be obtain in sub-optimal conditions, less influence by patient motivation. Further analyses are in progress to confirme this preliminary results and to determine the optimal threshold.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4401.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).