PT  - JOURNAL ARTICLE
AU  - Sarah Scharm
AU  - Sabine Dettmer
AU  - Jens Vogel-Claussen
AU  - Antje Prasse
AU  - Lars Knudsen
AU  - Frank Wacker
AU  - Jan Fuge
AU  - Hoen-Oh Shin
TI  - Combined assessment of regional lung function and morphology using a contrast enhanced Dual-Energy CT protocol: Prospective value of functional imaging biomarkers in longitudinal analysis of patients with Interstitial Lung Disease
AID  - 10.1183/13993003.congress-2020.4575
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 4575
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/4575.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/4575.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Purpose: Aim of the study was to evaluate whether functional CT-derived parameters serve as early imaging biomarkers for disease progression in patients with Interstitial Lung Disease (ILD).Material and Methods In 38 patients with ILD, paired scans (time interval 13.7 months ± 5.4 months) were performed with a newly developed contrast-enhanced scan protocol in inspiration and delayed expiration. Virtual Unenhanced Non Contrast (VNC) and Pulmonary Blood Volume (PBV) images were generated for both breathing positions. The PBV images served as surrogate for lung perfusion and late enhancement. The VNC images in inspiration and expiration were registered and fractional ventilation images were calculated. Lung perfusion, late enhancement and fractional ventilation of the baseline were correlated with longitudinal parameter changes (follow-up/baseline) of FVC%, DLCO%, and functional lung volume.Results: Fractional ventilation and late enhancement parameters of the baseline scan predict future change in functional lung volume (R -0.765, p 0.000 / R -0.558, p 0.001). The fractional ventilation also correlated with future change in FVC% and DLCO% (R -0.411, p 0.022 / R -0.556, p 0.003).Conclusion: CT-derived functional parameters are potential early imaging biomarkers for ILD.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4575.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).