TY - JOUR T1 - Genetic polymorphisms of IL6, IL10, TNF-a and IL4R and associations with the risk of chronic obstructive pulmonary disease in a sample of Belarusian population JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.1127 VL - 56 IS - suppl 64 SP - 1127 AU - Catherine Khotko AU - Aliaksei Kadushkin AU - Anatoli Tahanovich Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/1127.abstract N2 - Methods: We performed a case-control study with 95 COPD subjects. Healthy controls (n=95) were selected from a group of people attending the physical examination and were frequency-matched to the cases by sex and age. The genetic variants were genotyped by real time fluorescence polymerase chain reaction (RT-PCR) with TaqMan probe technology.Results: Exact Hardy–Weinberg equilibrium (HWE) tests were performed for each SNP. The genotype distributions of IL6 and IL4R were differed significantly in non-smoking COPD patients and non-smoking controls (χ2=7.69, p=0.006 and χ2=5.74, p=0.017, respectively). The frequency of wild genotype C/C (IL6) was higher in the control group compared to COPD patients (63.9% vs. 30.0%). Homo- or heterozygous carrier state with minor allele G of IL6 indicates 4.1-fold higher risk of COPD (95% CI: 1.5-11.6). Individuals carrying rs1801275 allele G had a reduced risk (OR=0.3; 95% CI: 0.1-0.8). Individuals carrying rs2275913 allele A had a reduced risk (OR=0.62; 95% CI: 0.46-0.86). Polymorphisms rs1800896 (IL10) and rs1800629 (TNF-α) were significantly associated with altered risk for COPD in smokers. Individuals carrying rs1800896 minor allele G had a decreased risk (OR=0.8; 95% CI: 0.4-1.7). Regarding minor allele A of rs1800629, it has been associated with higher risk of COPD (p=0.0002, OR=3.9; 95% CI: 1.7-9.4).Conclusion: The genotype variants rs1801275 (IL4R), rs1800795 (IL6), rs1800896 (IL10) and rs1800629 (TNF-α) contribute to the prediction of COPD and may be used as the marker for the early disease prevention in risk groups of the Belarusian population.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1127.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -