TY - JOUR T1 - Follow-up of children after resection for congenital thoracic malformations JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.3521 VL - 56 IS - suppl 64 SP - 3521 AU - Emma Longoni AU - Giulia Maria Luisa Cammi AU - Laura Paradiso AU - Michele Ghezzi AU - Marco Morelli AU - Andrea Farolfi AU - Enza Carmina D'Auria AU - Gianvincenzo Zuccotti Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/3521.abstract N2 - We retrospectively analyzed complications and long-term pulmonary function test (PFT) in 115 children with congenital thoracic malformations after pulmonary resection.Congenital pulmonary airway malformationwas found in 40% of patients, pulmonary sequestration in 25%, congenital lobar emphysema in 10%, bronchial atresia in 4%, complex malformations in 9%, others in 10%. The most frequent type of resection was lobectomy (66%), followed by wedge resection (15.6%), segmentectomy (8.7%), pneumonectomy (4.3%). Average age at surgery was 21 months. 41.8% of patients had symptoms before surgery (16% respiratory distress, 8% pneumothorax, 7% recurrent pulmonary infections).In our series 76% of children reported long-term complications such as cough, recurrent infections, wheezing, low effort tolerance, mild scoliosis, pectus excavatum, chest X-ray abnormalities, postpneumonectomy syndrome.Nevertheless these were not statistically correlated with surgery before or after 6 months and thoracoscopy vs thoracothomy, but they were associated with segmentectomy (p-value 0.043) and not with lobectomy.We also evaluated PFT after surgery in 86/115 children at average age of 9.7 years. Restrictive pattern was found in 20%, obstructive deficit in 13%. Resection after 6 months was correlated with restrictive pattern (p-value 0.047).The lung has some capacity to organize a catch-up growth with alveolarization during childhood, for this reason we found no differences in PFT between health children and resected ones, as described in literature. Most of them enter adult life with normal PFT;but at the same time, later resections could not be completely compensated by pulmonary catch-up growth.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3521.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -