TY - JOUR T1 - Association between young age and genomic alterations in never-smoker patients with non–small cell lung cancer JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.1748 VL - 56 IS - suppl 64 SP - 1748 AU - Wenxin Luo AU - Weimin Li Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/1748.abstract N2 - Objective: The purpose of this study was to explore the relationship between young age and genomic alterations in never-smoker patients with non-small cell lung cancer (NSCLC).Methods: A cohort of 638 never-smoker patients with NSCLC were classified into: young group (≤ 45 years), middle-young age group (46-60 years), middle-old age group (61-75 years) and old group (≥76 years). Targeted region sequencing covering eight potentially targetable genomic alterations was conducted on the tumor tissue before anti-tumor therapy.Results: Genomic alterations for ALK (p<0.001) and ERBB2 (p=0.023) were positively associated with younger age, and a similar trend existed for ROS1 (p=0.131). There was a significantly negative correlation between EGFR alterations and younger age (p < 0.001). However, no association was observed between younger age and KRAS, RET, MET and BRAF alterations. In total, there was 72.3% of patients harboring a targetable genomic alteration in young group, 78.1% in middle-young age group, 75.2% in middle-old age group and 76.7% in old group; and the difference was not significantly (p=0.670).Conclusions: Younger age is associated with an increased likelihood of harboring ALK, ERBB2 and ROS1 alterations, and is associated with a decreased possibility of harboring EGFR. The spectrum of targetable genomic alterations in young never-smoker patients with NSCLC is different from that in older patients.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1748.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -