PT  - JOURNAL ARTICLE
AU  - Armin Frille
AU  - Nicolas Linder
AU  - Johanna Pappisch
AU  - Teresa Kerkhoff
AU  - Jonas Meyer
AU  - Hartmut Kuhn
AU  - Claudia Hänel
AU  - Harald Busse
AU  - Karen Geva Steinhoff
AU  - Michael Rullmann
AU  - Thomas Ebert
AU  - Sebastian Krämer
AU  - Johannes Broschewitz
AU  - Osama Sabri
AU  - Swen Hesse
AU  - Hans-Jürgen Seyfarth
AU  - Hubert Wirtz
TI  - Interactions of lung cancer with adipose and muscle tissue in the development of cancer cachexia
AID  - 10.1183/13993003.congress-2020.3943
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 3943
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/3943.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/3943.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Introduction: Cancer cachexia (CC) is often experienced by lung cancer patients (LCP). It is associated with shrinkage of skeletal muscle mass, immobility, reduced quality of life, and shorter patient survival. Brown (BAT) and white adipose tissue (WAT), plus abdominal muscle mass play a role in the development of CC.Aims: We aimed to find out whether and how adipose and muscle tissue interacts with LC in CC.Methods: Retrospectively, 200 LCP and 30 healthy controls (HC) were analysed for BAT activation via fluorine-18 deoxyglucose positron emission tomography/computed tomography. Mean standardized uptake values (SUVmean) of predefined regions of interest (ROI) in the retroclavicular fat were measured, normalized to liver uptake and reported as SUV ratio (SUVR). ROIs from transversal CT images were used to quantify visceral adipose (VAT) and abdominal muscle mass. Prospectively, 50 LCP were likewise analysed for BAT activation and additionally underwent bioelectrical impedance analysis to assess body composition and analysis of circulating adipokines via enzyme-linked immunosorbent assay.Results: LCP showed higher SUVR in BAT than the HC. Higher SUVR in BAT was associated with lower BMI (r=-0.38) and reduced VAT (r=-0.44). LCP with higher SUVR in BAT were associated with significant weight loss (odds ratio 2.3, P<0.05). These results were confirmed in the prospective cohort. Circulating adiponectin levels positively correlated with SUVR in BAT (r=0.71) and inversely with both BMI (r=-0.61), VAT (r=-0.58) and lean body mass (r=-0.53).Conclusions: LCP express higher BAT activity than HC, which is correlated with CC. Adiponectin is associated with BAT activation and leaner body composition.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3943.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).