PT - JOURNAL ARTICLE AU - Zhiling Zhao AU - Xiaojuan Wang AU - Wuzhuang Sun AU - Xiaoyun Zhao AU - Yingxiang Lin AU - Shu Zhang AU - Zhaohui Tong TI - Effectiveness of inspiratory plus expiratory neuromuscular electrical stimulation in the rehabilitation of patients with severe COPD AID - 10.1183/13993003.congress-2020.1826 DP - 2020 Sep 07 TA - European Respiratory Journal PG - 1826 VI - 56 IP - suppl 64 4099 - http://erj.ersjournals.com/content/56/suppl_64/1826.short 4100 - http://erj.ersjournals.com/content/56/suppl_64/1826.full SO - Eur Respir J2020 Sep 07; 56 AB - Introduction: Neuromuscular electrical stimulation (NMES) contributes to COPD rehabilitation, but the current NMES therapy only works on inspiratory phase.Objectives: The purpose of this study was to compare the intervention effectiveness of inspiratory plus expiratory NMES (IENMES) with inspiratory NMES (INMES) in COPD patients.Methods: 120 patients (receiving standard treatment) with severe and very severe stable COPD (GOLD3 and GOLD4) were randomly divided into the IENMES group (n=60) and the INMES group (n=60). The IENMES group patients were treated with Respiratory Neuromuscular Stimulator (Yaguo Technology Ltd, Beijing, China). Patients in both groups were given treatment once a day for 30 minutes, and totally for 4 weeks. The 6-min walking distance (6MWD), mMRC, FEV1, FEV1% pred, FEV1% FVC, MVV and PEF were observed before and after treatment.Results: After 4 weeks of treatment, 6MWD was more improved in IENMES group (65.53±39.45m) compared with INMES group (26.66±32.65m); mean between-group difference was 29.07m ([95% CI 16.098 to 42.035]; p<0.001). There was no significant difference in the other parameters between the two groups. For GOLD4 subjects, FEV1, FEV1%pred, FEV1%FVC were significantly improved in IENMES group (p<0.05).Conclusion: Compared with the INMES treatment, IENMES treatment is better in improving the exercise endurance of patients with severe and very severe COPD in stable phase and improving the lung ventilation of patients with very severe COPD, which indicates that IENMES has significant effectiveness in promoting the pulmonary rehabilitation of patients with severe COPD.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1826.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).