@article {Pourbazargan3371, author = {Melvin Pourbazargan and Sven Nyren and Petra Um-Bergstr{\"o}m and Eva Berggren-Brostr{\"o}m and Erik Mel{\'e}n and Rebecka Steern and {\r A}sa M Wheelock and Anders Lind{\'e}n and Reza Karimi and C Magnus Sk{\"o}ld}, title = {Structural changes on high resolution computed tomography (HRCT) in adult individuals with a history of bronchopulmonary dysplasia (BPD)}, volume = {56}, number = {suppl 64}, elocation-id = {3371}, year = {2020}, doi = {10.1183/13993003.congress-2020.3371}, publisher = {European Respiratory Society}, abstract = {Bronchopulmonary dysplasia (BPD) in infancy is a risk factor for lung disease later in life. We aimed to characterize structural abnormalities by high resolution computed tomography (HRCT) in adult individuals born preterm. We included individuals born preterm (\<32 gestational weeks) with (n=24) or without (n=23) a previous diagnosis of BPD, and compared them to patients with mild allergic asthma (\>37 weeks, n=22) and healthy controls (\>37 weeks, n=24) from the LUNAPRE cohort (clinicaltrials.gov/ct2/show/NCT02923648). Their median (range) age was 19.8 (18.3-24.0) years. All participants underwent inspiratory and expiratory HRCT scans which blindly were interpreted by two experienced reviewers using a scoring system.Linear/triangular subpleural lung opacities (p\<0.05 for both), and local hypoattenuation (p\<0.01) were more common in individuals with BPD compared to the other groups. Architectural distortion was more common in the BPD group compared to healthy controls and asthmatic individuals (p\<0.01, p\<0.05).Bronchial wall thickening was more frequent in the BPD group compared to healthy and premature individuals (p\<0.05 for both). In individuals with BPD, air trapping was predominant compared to healthy controls (p\<0.05). At least one HRCT abnormality was found in most (92\%) premature with BPD compared to premature without BPD (74\%), asthmatics (73\%) and healthy controls (62\%).We conclude that most young adults with a history of BPD have structural lung abnormalities on HRCT, which is likely a consequence of lung insults in the neonatal period. These findings may be linked to functional impairment and lung disease later in adulthood.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3371.This abstract was presented at the 2020 ERS International Congress, in session {\textquotedblleft}Respiratory viruses in the "pre COVID-19" era{\textquotedblright}.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/56/suppl_64/3371}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }