PT  - JOURNAL ARTICLE
AU  - Nara Higano
AU  - Stephanie Adaikalam
AU  - Erik Hysinger
AU  - Alister Bates
AU  - Robert Fleck
AU  - Andrew Schapiro
AU  - Melissa House
AU  - Amy Nathan
AU  - Shawn Ahlfeld
AU  - Jennifer Brady
AU  - Andrew Hahn
AU  - Sean Fain
AU  - Paul Kingma
AU  - Jason Woods
TI  - Clinically-relevant tracheostomy prediction model in neonatal bronchopulmonary dysplasia via respiratory MRI
AID  - 10.1183/13993003.congress-2020.4789
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 4789
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/4789.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/4789.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Background: There are few prognostic indicators of need for tracheostomy in preterm infants with chronic lung disease (bronchopulmonary dysplasia, BPD).Aims: To develop a clinically-useful tracheostomy prediction model in neonatal BPD using quantitative biomarkers from respiratory MRI.Methods: Infants with and without BPD (N=61) underwent 3D lung and airway MRI (0.7 mm3) near term-age. Lung disease scores (0-14 points) were used to create a binomial logistic regression model (⅔*N) to determine likelihood of tracheostomy (yes/no tracheostomy outcome assigned by 75% probability threshold), with validation in a separate cohort (⅓*N). A sub-cohort model also included MRI-quantified tracheomalacia severity (n=36).Results: The model correctly classified 95% of the validation cohort. The full-cohort model had 89% accuracy, 100% positive predictive value, and 85% negative predictive value. The lung+airway model values were 83%, 92%, and 78%, respectively.Conclusions: Quantitative respiratory MRI can predict need for tracheostomy in neonatal BPD with high sensitivity and accuracy, providing an objective tool for clinical decision-making.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4789.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).