TY - JOUR T1 - Unrevealed Structural, Functional and Immunological Pulmonary Changes Induced by Metabolic Syndrome in Elderly JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.5113 VL - 56 IS - suppl 64 SP - 5113 AU - Maysa Rangel AU - Renilson M Ferreira AU - Luis Vicente F Oliveira AU - Claudio R Frison AU - Rodolfo P Vieira Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/5113.abstract N2 - Metabolic syndrome (MS) is highly prevalent among elderly and it induces impairment in the lung function and is underlined by low-grade inflammation. By now, no study has investigated if such alterations driven by MS affects the structural and immunological response of the lungs. Thus, this study used impulse oscillometry to functionally evaluate the structural pulmonary alterations and the measurement of pro and anti (inflammatory and fibrotic) mediators in the breath condensate, to assess the immunological response in the lungs of 77 elderlies (67,44±6,03 years old) without MS and 75 elderlies (68,52±5,98 years old) with MS. Some differences were observed in the spirometric values (FEV1, p<0.0007; PEF, p<0.0003; MEF25, p<0.003; MEF75, p<0.0001) comparing non-MS with MS elderly. However, a significant increase in total resistance of respiratory system (R5Hz; p<0.0091), in resistance of proximal (R20Hz; p<0.0011) and distal (R5Hz-R20Hz; p<0.04) airways was observed in MS elderly. Since these changes in R5Hz, R20Hz and R5Hz-R20Hz may occurs due to airway inflammation and remodeling, the analysis of pro-inflammatory (leptin; IL-1beta; IL-8, p<0.0001; TNF-alpha, p<0.04), anti-inflammatory cytokines (adiponectin; IL-1ra; IL-10; p<0.0001), anti-fibrotic (relaxin 1; relaxin 3; Klotho, p<0.0001) and pro-fibrotic (VEGF, p<0.0001) factors, revealed that MS induces a pulmonary pro-inflammatory and pro-fibrotic response. IOS is an important tool to differentiates the lung function and mechanics of elderly with MS, who present increased airway resistance involving increases in pulmonary pro-inflammatory and pro-fibrotic mediators.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 5113.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -