PT  - JOURNAL ARTICLE
AU  - Bayat, Sam
AU  - Broche, Ludovic
AU  - Machichi, Mohammed
AU  - Bailly, Sébastien
AU  - Degano, Bruno
AU  - Tamisier, Renaud
AU  - Ferretti, Gilbert
AU  - Pépin, Jean-Louis
TI  - Comparison of low-dose CT image registration-based “Parametric Response Maps” with global lung function and diffusion capacity in COPD patients
AID  - 10.1183/13993003.congress-2020.2198
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 2198
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/2198.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/2198.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Background: There is a growing interest in image-based markers of regional lung function as predictive prognostic factors in COPD patients. Here we compare ‘parametric response maps’ (PRM) based on the change in lung attenuation between expiratory and inspiratory CT images with global lung function parameters, in a prospective cohort of COPD patients.Methods: Following ethical authorization and informed consent, we classified lung CT image voxels based on the change in attenuation between maximal expiration and inspiration, as: Normal; Emphysema; Trapping and Emptying Emphysema, according to [1] (Figure).Results: See: Table; 31 patients were included in the study (median age: 65 y (IQR: 60-71); Female/Male: 39%. Gold stages 1, 2, 3 & 4 represented 13%; 45%; 26% and 16% respectively. PRM clusters were not significantly different between Gold stages.Conclusions: PRM indices based on 3D registration of expiratory and inspiratory CT images were significantly correlated to global lung function and diffusion capacity in COPD patients. These indices are promising and merit further evaluation as surrogate markers in COPD patients. 1. Galban, C. J. et al. Nat Med 2012;18:1711-1715, doi:10.1038/nm.2971.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2198.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).