RT Journal Article SR Electronic T1 Factors associated with lung cancer in patients referred to a fast-track clinic JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 2915 DO 10.1183/13993003.congress-2020.2915 VO 56 IS suppl 64 A1 Helen Mcdill A1 Jon Noble A1 Eleanor Barton A1 Clemency Clarke A1 Martin Plummeridge A1 Andrew Low A1 Anna Bibby YR 2020 UL http://erj.ersjournals.com/content/56/suppl_64/2915.abstract AB Background: Almost 50,000 people are diagnosed with lung cancer each year in the UK, with more referred for investigations via fast track pathways. The aim of this study was to explore the factors associated with malignancy in patients referred to lung cancer services and the impact this could have on streamlining referrals.Methods: Patients referred to two UK tertiary centres between 01/01/2017 and 31/12/2017 were included. Clinical history was extracted from medical records and radiological images reviewed. Multivariable logistic regression modelling was used to evaluate factors associated with lung cancer.Results: 835 patients were referred, of whom 244 (29.2%) were diagnosed with cancer. Malignant diagnoses included lung cancer (small cell and non-small cell), mesothelioma, carcinoid and pulmonary metastases. Non-cancer diagnoses included infection, COPD/Asthma nodules, bronchiectasis and unknown diagnosis.Factors associated with a diagnosis of cancer included increasing age, smoking history (pack years), weight loss at presentation and an abnormal or highly suspicious chest x-ray (Table 1).Conclusion: The majority of people referred to lung cancer clinic did not have cancer. Patient characteristics can help stratify risk, but ultimately radiology was the strongest predictor of malignancy. This data could inform pathway design to reduce time to diagnosis. FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2915.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).