PT  - JOURNAL ARTICLE
AU  - Ekaterina Makarova
AU  - Marina Milutina
AU  - Vasily Fedotov
AU  - Nikolay Menkov
AU  - Nataliya Lyubavina
AU  - Svetlana Plastinina
TI  - Arterial stiffness in patients with chronic obstructive pulmonary disease combined with arterial hypertension
AID  - 10.1183/13993003.congress-2020.2983
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 2983
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/2983.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/2983.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Chronic obstructive pulmonary disease (COPD) and arterial hypertension are common non-communicable diseases.The aim of the study: to investigate the vascular stiffness in patients having a combination of COPD and arterial hypertension compared with patients with essential arterial hypertension.Materials and Methods: The cross-sectional study included 78 people. The 1st group consisted of 39 people with COPD GOLD stages I-II combined with arterial hypertension (59.1 [56; 62] years). The 2nd group included 39 people with arterial hypertension (56.5 [52; 61] years). The groups were comparable by gender and age. Exclusion criteria were age>65 years, obesity, diabetes mellitus, ‎secondary arterial hypertension. Cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness was determined using volume sphygmography (VaSera VS 1500 N). Total cholesterol, high- and low-density lipoproteins were also analyzed.Results: The median value of CAVI exceeded the conditional normal level (8.0) in both groups. In the 1st group CAVI was significantly higher than in the patients with isolated arterial hypertension (8.9 [8.3; 9.5] and 8.2 [7.4; 9.1], respectively, p=0.02). CAVI values exceeding the normal level were registered in 82% of patients in the 1st group and 62% of patients in the 2nd group (p=0.02). There were no differences in the cholesterol or lipoproteins content between the groups.Conclusion: The arterial stiffness in patients having COPD combined with arterial hypertension is higher than in patients with isolated arterial hypertension. This may be due to low-intensity systemic inflammation that exacerbates endothelial damage in COPD.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2983.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).