@article {Sarkar1009, author = {Trina Sarkar and Lancelot Pinto and Ashok Mahashur}, title = {Prevalence,determinants and impact of nocturnal hypoxemia in COPD patients not candidates for domiciliary oxygen therapy}, volume = {56}, number = {suppl 64}, elocation-id = {1009}, year = {2020}, doi = {10.1183/13993003.congress-2020.1009}, publisher = {European Respiratory Society}, abstract = {Background: Patients with chronic obstructive pulmonary disease (COPD) frequently manifest sleep-related breathing disorders. Reported prevalence of significant nocturnal desaturation (NOD) varies from 25-46\%,with limited information on its determinants and impact.Aims: To estimate the prevalence,determinants and impact of NOD in stable patients with COPD who are not candidates for domiciliary oxygen therapy.Methods: Consecutive patients with COPD with daytime oxygen saturation (SpO2) \>90\% with no symptoms or prior diagnosis of obstructive sleep apnea (OSA) underwent overnight level 3 home sleep study. Demographics, spirometry results and COPD assesment test (CAT) questionnaire scores were recorded. Significant NOD was defined as nocturnal SpO2 \<88\% for atleast 5 minutes.Results: 42 patients underwent a sleep study. 28 patients (66.7\%) had significant NOD. 21 of these patients had an apnea hypopnea index \> 15 indicating presence of underlying obstructive sleep apnea (OSA). Recorded day time SpO2 was the only predictor of NOD;all patients with day-time SpO2\<96\% exhibited significant NOD. NOD was not significantly correlated with degree of obstruction on spirometry or CAT scores.Conclusion: Significant NOD is common among patients with COPD. Patients with COPD should be screened for NOD and OSA, especially when the day time SpO2 is less than 96\%. This decision to screen should be made irrespective of the stage of the disease and CAT scores.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1009.This abstract was presented at the 2020 ERS International Congress, in session {\textquotedblleft}Respiratory viruses in the "pre COVID-19" era{\textquotedblright}.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/56/suppl_64/1009}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }