TY - JOUR T1 - Study of relation between weaning failure from mechanical ventilation and cardiac dysfunction in Intensive Care patients JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.3438 VL - 56 IS - suppl 64 SP - 3438 AU - Radwa Elhefny AU - Sherif Zaki AU - Osama Momtaz AU - Rabab Fawzy Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/3438.abstract N2 - Machinal ventilation (MV) is performed with respiratory failure caused by respiratory muscles and/or lung parenchymal disease. A successful weaning from mechanical ventilation depends not only on adequate respiratory muscle strength & endurance but also on optimal performance of other organs including the heart. Weaning-induced cardiac ischemia as weaning increases cardiac work and myocardial O2 demand. B type natriuretic peptide (BNP) is a protein released from the cardiac ventricles in response to stretch. Our aim is to study relation between weaning failure from MV and cardiac dysfunction by using N-terminal pro BNP and Echocardiography.Methods: 30 patients with difficult weaning who underwent spontaneous breathing trial (SBT). Echocardiography was done and sampling of N-BNP at start of MV and at SBT.Results: Rapid shallow breathing index(RSBI) is increased significantly from start on MV than SBT(108.1±9.8 vs.40.6±6.9 breath/min/l) & PO2/ FIO2 was decreased significantly from start on MV than SBT (206.3±38 vs. 111.4±17.5). ECHO data showed diastolic dysfunction and grade ІІ in 70% and grade І in 30%, there was significant increase in N -BNP from start of MV than SBT (15275±6667.7vs 1599.7±1448.7 ng/L). The N-BNP cutoff point of 1765 ng/L at start of MV with sensitivity 78.3% & 18500 ng/L at SBT with sensitivity 87%.Conclusions: N-BNP and left ventricular diastolic dysfunction at start of MV can be used to predict weaning failure in MV patients due to cardiac cause.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3438.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -