RT Journal Article
SR Electronic
T1 Late Breaking Abstract - Increased risk of pulmonary embolism in patients with radiological severe COVID-19 pneumonia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 3596
DO 10.1183/13993003.congress-2020.3596
VO 56
IS suppl 64
A1 Cristiano van Zeller
A1 Claudette Phillips
A1 Adrian Draper
A1 Michael Bridgett
A1 Yee-Ean Ong
A1 Sisa Grubnic
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/3596.abstract
AB Introduction: COVID-19 pneumonia is associated with a higher incidence of pulmonary embolism (PE) than is observed in other viral pneumonias (1)Our aim was to assess if d-dimer (DD) and radiological severity of COVID-19 were associated with PE in patients with COVID-19 pneumoniaMethods: We retrospectively analysed all consecutive emergency CTPAs performed in our institution between 13 March and 8 May 2020. CTPAs were reviewed by a thoracic radiologist for the presence of PE and severity of COVID-19. Data was analysed using STATA version 16.1. Subjects were grouped into quintiles by age. Odds ratios were adjusted for age and sex. DD cut-points were estimated according to Liu methodResults: 301 patients were included (151 female, median age 61 [18,94] years). Men were more likely to be admitted to ITU (37% vs 17%, p < 0.001). 239 patients had a DD level. Compared with those without radiological evidence of COVID (n = 158), patients with radiologically severe disease (n = 68) were most likely to have a PE (OR 2.89, p = 0.004. 95% CI [1.39-6.00]). DD cutpoints are presented in table 1 View this table:Table 1 DD (ng/ml) according to radiological COVID status and ITU admission (n, sensitivity (%), specificity (%), AUC)Conclusion: The prevalence of PE was associated with severe radiological COVID-19. DD was not discriminatory in PE diagnosisReferences1. Bompard F, Monnier H, Saab I, et al. Pulmonary embolism in patients with Covid-19 pneumonia. Eur Respir J 2020; in press (https://doi.org/10.1183/13993003.01365-2020)FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3596.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).