PT  - JOURNAL ARTICLE
AU  - Charles Moulin
AU  - Philippe Girard
AU  - Agathe Seguin-Givelet
AU  - Konstantinos Zannis
AU  - Laurent Tric
AU  - Jean-Luc Leguillou
AU  - Thibault Vieira
AU  - Dominique Gossot
AU  - Christian Lamer
TI  - Early venovenous extracorporeal membrane oxygenation for idiopathic post-pneumonectomy pulmonary edema
AID  - 10.1183/13993003.congress-2020.4093
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 4093
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/4093.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/4093.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Introduction: Idiopathic post-pneumonectomy pulmonary edema (iPPE) is a rare but extremely severe complication of thoracic surgery. Mortality can reach 100 % especially after right pneumonectomy.Objective: This study aimed to report the results of a strategy of early venovenous extracorporeal membrane oxygenation (vvECMO) in iPPE and to compare the results with those observed during a previous 6 years control period.Methods: Since October 2010 , all patients diagnosed as iPPE were treated with early vvECMO associated with ultraprotective mechanical ventilation. Outcomes were compared with iPPE patients treated with conventional mechanical ventilation over the 2004-2010 period.Results: Between October 2010 and December 2017, 150 pneumonectomies were performed ; 6 (mean age = 59.6 y ; 4 right pneumonectomies) patients developped iPPE and were treated with early vvECMO (mean time to ECMO = 3 days after surgery, range: 2 to 6 days) Mean durations of ECMO, mechanical ventilation and ICU stay were 8.6, 31.3, 39.2 days respectively. All patients survived and could be discharged from hospital. Four patients experienced a complication directly related to the vvECMO (major hemorrhage, n = 1 ; bacteremia with septic shock, n = 1 ; deep venous thrombosis, n = 2). During the control period 5 iPPE (mean age = 69 yrs ; 4 right pneumonectomies) occurred among 218 patients. All patients died during their ICU stay after a mean duration of 8.5 days.Conclusion: This study suggests that early vvECMO should be considered as a life-saving therapy in iPPE .FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4093.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).