RT Journal Article
SR Electronic
T1 Late Breaking Abstract - Comparison of VATS debulking surgery and HITHOC vs VATS talc pleurodesis alone in malignant pleural mesothelioma: a pilot study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4489
DO 10.1183/13993003.congress-2020.4489
VO 56
IS suppl 64
A1 Marcello Migliore
A1 Marco Nardini
A1 Alfreda Meli
A1 Corrado Spatola
A1 Ines Monte
A1 Tommaso Nicolosi
A1 Mariacristina Scuderi
A1 Hector Soto Parra
A1 Marco Aiello
A1 Paolo Vigneri
A1 Giovanna Fantaci
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/4489.abstract
AB Introduction: Although several Authors have emphasized the importance of surgery to obtain long term survival in malignant pleural mesothelioma (MPM), no study identifies evident reasons to convince surgeons to decide for one or another technique.Aim: prospective randomized bi-centric pilot study to investigate the effects and survival of VATS debulking surgery and HITHOC vs VATS-talc pleurodesis in MPM.Method: Patients with MPM were assigned to 2-groups: a) VATS-talc pleurodesis; b) VATS-PD and HITHOC. Several factors and Kaplan-Meier survival curves have been analyzed.Results: 27 patients, 24 male, mean-age 66 (48-82) were enrolled. All patients were stage I-II. 14 pts in group A, 13 pts group B. Age, stage, histology, early complication, hospital stay and quality of life did not differ. Survival after the operation was 19.6 months (group A) vs 31.6 months (group B). Survival after diagnosis was 19.6 months (group A) vs 33.0 (group B). One and 2-year survival was 57% and 28,6% for group A and 69% and 54% group B. A divergent curve at Kaplan Meier analysis at 3 years (fig 1). One patient of group B underwent 2 reoperation. Mortality was 0.Conclusion: VATS debulking surgery and HITHOC may be preferred in MPM because 3-year survival was longer compared to VATS pleurodesis, while safety and tolerability were similar. This study could stimulate larger randomized studies.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4489.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).