PT  - JOURNAL ARTICLE
AU  - Marcello Migliore
AU  - Marco Nardini
AU  - Alfreda Meli
AU  - Corrado Spatola
AU  - Ines Monte
AU  - Tommaso Nicolosi
AU  - Mariacristina Scuderi
AU  - Hector Soto Parra
AU  - Marco Aiello
AU  - Paolo Vigneri
AU  - Giovanna Fantaci
TI  - Late Breaking Abstract - Comparison of VATS debulking surgery and HITHOC vs VATS talc pleurodesis alone in malignant pleural mesothelioma: a pilot study
AID  - 10.1183/13993003.congress-2020.4489
DP  - 2020 Sep 07
TA  - European Respiratory Journal
PG  - 4489
VI  - 56
IP  - suppl 64
4099  - http://erj.ersjournals.com/content/56/suppl_64/4489.short
4100  - http://erj.ersjournals.com/content/56/suppl_64/4489.full
SO  - Eur Respir J2020 Sep 07; 56
AB  - Introduction: Although several Authors have emphasized the importance of surgery to obtain long term survival in malignant pleural mesothelioma (MPM), no study identifies evident reasons to convince surgeons to decide for one or another technique.Aim: prospective randomized bi-centric pilot study to investigate the effects and survival of VATS debulking surgery and HITHOC vs VATS-talc pleurodesis in MPM.Method: Patients with MPM were assigned to 2-groups: a) VATS-talc pleurodesis; b) VATS-PD and HITHOC. Several factors and Kaplan-Meier survival curves have been analyzed.Results: 27 patients, 24 male, mean-age 66 (48-82) were enrolled. All patients were stage I-II. 14 pts in group A, 13 pts group B. Age, stage, histology, early complication, hospital stay and quality of life did not differ. Survival after the operation was 19.6 months (group A) vs 31.6 months (group B). Survival after diagnosis was 19.6 months (group A) vs 33.0 (group B). One and 2-year survival was 57% and 28,6% for group A and 69% and 54% group B. A divergent curve at Kaplan Meier analysis at 3 years (fig 1). One patient of group B underwent 2 reoperation. Mortality was 0.Conclusion: VATS debulking surgery and HITHOC may be preferred in MPM because 3-year survival was longer compared to VATS pleurodesis, while safety and tolerability were similar. This study could stimulate larger randomized studies.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4489.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).