RT Journal Article SR Electronic T1 Decreased mortality with rollout of electronic pneumonia clinical decision support across 16 Utah hospital emergency departments JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 4667 DO 10.1183/13993003.congress-2020.4667 VO 56 IS suppl 64 A1 Nathan Dean A1 Caroline Vines A1 Jenna Rubin A1 Brandon Webb A1 Jason Jacobs A1 Allison Butler A1 Jaehoon Lee A1 Al Jephson A1 Nathan Jenson A1 Missy Walker A1 Jeremy Irvin A1 Matthew Lungren A1 Jason Carr A1 Raj Srivastava A1 Todd Allen YR 2020 UL http://erj.ersjournals.com/content/56/suppl_64/4667.abstract AB Introduction: ePNa open loop, electronic clinical decision support improved mortality and disposition for emergency department (ED) community-acquired pneumonia patients in 4 intervention hospitals vs 3 usual care hospitals (Annals EM 2015 66:511). ePNa provides ED clinicians with support for diagnosis and objective severity measurement, then disposition and antibiotic recommendations based on the DRIP score. We rolled out ePNa across 16 additional Intermountain Healthcare (Utah, USA) Hospitals beginning 2018 in a stepwise implementation trial.Objectives: Evaluate whether ePNa might improve clinical outcomes in a diverse group of non-teaching hospitals.Methods: 7293 ED patients >18 years 2017 to 2019 with complete data were identified electronically by ICD-10 codes; patients without confirmatory chest imaging (CheXED, Stanford AI model) were excluded.Results: Median age was 67 (IQR 52-79) years, 48% female.ePNa: use by clinicians averaged 47.4% after rollout but varied from 10% to 92% by month and hospital. Intention to treat analysis showed 30-day mortality of 5% (146/3101) vs 10% (417/4192) before rollout; outpatient disposition increased from 21% vs 48%. 7-day secondary hospitalization was 1% vs 3% after rollout. 30-day all-cause mortality was significantly lower after severity adjustment (electronicCURB, age, PaO2/FiO2, pleural effusion, HCAP, gender) by logistic regression (OR 0.57, 95% CI 0.46,0.69, p <.001).Conclusions: Rollout of ePNa clinical decision support into 16 hospital ED was associated with decreased mortality and hospital admission among pneumonia patients. We plan further interventions to increase ePNa use by ED clinicians.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4667.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).