RT Journal Article
SR Electronic
T1 Late Breaking Abstract - WEAning From NonInvasive Ventilation – ‘WEANIV’ Study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4351
DO 10.1183/13993003.congress-2020.4351
VO 56
IS suppl 64
A1 Aylin Özsancak Ugurlu
A1 Zuhal Karakurt
A1 Raffaele Scala
A1 Ezgi Ozyilmaz
A1 Begum Ergan
A1 Stefano Nava
A1 Fabiano Dimarco
A1 Eylem Tuncay
A1 Giuseppina Ciarleglio
A1 Orhan Othman Hasan
A1 Sara Betti
A1 Lisa Giuliani
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/4351.abstract
AB Introduction: There is no evidence about the best strategy to wean patients with acute hypercapnic respirtaory failure (AHRF) from a successful noninvasive ventilation (NIV) treatment.Aim: A multicenter RCT to compare the effectiveness of 3 different strategies in terms of successful rate of weaning and duration of NIV; as well as mortality, length of stay (LOS) in hospital, respiratory ICU (RICU) and ICU.Methods: 197 adult patients successfully treated with NIV for AHRF were prospectively randomized to gradual decrease in duration of NIV (A, n=66), gradual decrease in duration and level of ventilator support (B, n=64), or abrupt discontinuation of NIV (C, n=67).Results: Baseline characteristics were similar in terms of age, gender, body mass index, smoking status, Charlson comorbidity and APACHE II scores, vitals and arterial blood gas findings at enrollment (p>0.05); except for higher incidence of pneumonia and cardiovascular comordities, lower pCO2 level and incidence use of home long-term oxygen-therapy in Group C (p<0.05).There was no difference between groups for NIV weaning success rates (p>0.05).The median duration of total NIV use after randomization and LOS in RICU was shorter in Group C (p<0.001 and p=0.044).However there was no significant differences in other secondary outcomes.Conclusion: Even though abrupt interruption may reduce NIV and RICU stay duration, all tested strategies are similarly effective in terms of NIV weaning success.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 4351.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).