RT Journal Article
SR Electronic
T1 The efficacy of the decamethoxin against simple and complex viruses
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 2388
DO 10.1183/13993003.congress-2020.2388
VO 56
IS suppl 64
A1 Galyna Gumeniuk
A1 Mykola Gumeniuk
A1 Iryna Dziublik
A1 Svitlana Fadeeva
A1 Svitlana Opimakh
A1 Oleksii Denysov
YR 2020
UL http://erj.ersjournals.com/content/56/suppl_64/2388.abstract
AB Background: Potentially effective antiviral agents are surfactant antiseptics, namely decamethoxin, which has a pronounced bactericidal, fungicidal and prostocidal effect also could has antiviral activity. The usage of the decamethoxin for the treatment of airway infections is pathogenetically justified due to the dosage form of a sterile solution for inhalation using a nebulizer in single-dose containers.Aim: to evaluate virucidal effect of decametoxine against simple and complex viruses in cell cultures.Methods: The virucidal effect of decamethoxin was studied by suspension method in re-grafted models of human laryngeal adenocarcinoma (HEP-2) and dog kidney (MDCK) cell cultures. Determination of the virus load was carried out according to the Kerber’s method as lgTCD50 (50% tissue cytopathic doses).Results: The complete inactivation in virus-containing fluids in infectious titers of 3.0 lg TCD50/0.1 ml for influenza A (H1N1) virus, 4.5 lg TCD50/0.1 ml for influenza A (H3N2) virus and 4.0 lg TCD50/0.1 ml for vesicular stomatitis virus (VSV) when exposure with decamethoxin lasts for 5 minutes or more took place. For simples viruses Human adenovirus (HAdV) and Poliovirus hominis virucidal effect was not established.Conclusion: The proven efficacy of the decamethoxin as an effective agent against complex viruses regardless of their antigenic structure gives the practical reasons for its usage in the airway infections including coronavirus.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 2388.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).