TY - JOUR T1 - Fibrosing cases of chronic eosinophilic pneumonia JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2020.3480 VL - 56 IS - suppl 64 SP - 3480 AU - Naoko Takeuchi AU - Toru Arai AU - Kazunobu Tachibana AU - Takayuki Takimoto AU - Yoshinobu Matsuda AU - Yu Kurahara AU - Kanako Katayama AU - Yukihiro Nakamura AU - Reiko Sugawara AU - Chikatoshi Sugimoto AU - Seiji Hayashi AU - Masanori Akira AU - Takahiko Kasai AU - Yoshikazu Inoue Y1 - 2020/09/07 UR - http://erj.ersjournals.com/content/56/suppl_64/3480.abstract N2 - Background and Objective: Chronic eosinophilic pneumonia (CEP) is a rare chronic onset disorder characterized by alveolar and/or blood eosinophilia. Most of the cases showed good prognosis; however, we sometimes experience fibrosing cases of CEP during follow-up period. Aim of this retrospective study was to clarify the frequency and clinical features of such cases.Subjects and Methods: We extracted 75 consecutive cases of CEP in our institution between 1999 and 2018. Sufficient information was obtained from medical records in 17 cases, and bronchoalveolar lavage (BAL) and/or high-resolution computed tomography (CT) at diagnosis was not performed in 11 cases. The rest of 47 cases were retrospective examined and we selected the 7 cases (14.9%) with an apparent fibrotic change on chest CT of last follow-up with observation period (IQR):3069 (1534-3466) days.Results: Fibrosing cases of CEP were consisted of four males and three females. The median (IQR) age at diagnosis was 64 years old (61-73 years). Two cases were never smokers, and no cases had history of asthma. Peripheral blood eosinophilia was 10.6% (IQR:7.5-14.8%), and BAL eosinophilia 8.6% (IQR: 4.2-12.9%). Flow-volume curve at diagnosis revealed normal (n=5), and restrictive (n=2) patterns. Obvious traction bronchiectasis on initial chest CT was not observed in any cases. Five cases received corticosteroid therapy. The fibrosing cases of CEP showed lesser percentages of eosinophils in peripheral blood and BAL than that of non-fibrosing cases (Wilcoxon rank sum test; p=0.0078 and p=0.010, respectively). At the last follow up, two cases died from acute exacerbation, and fungal infection.Conclusion: We experienced 7 fibrosing cases of CEP and their prognosis might be poor.FootnotesCite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 3480.This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -